{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:07:42Z","timestamp":1790489262357,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Philips Respironics"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Average volume\u2010assured pressure support\u2014automated expiratory positive airway pressure (AVAPS\u2010AE) combines an automated positive expiratory pressure to maintain upper airway patency to an automated pressure support with a targeted tidal volume. The aim of this study was to compare the effects of 2\u2010month AVAPS\u2010AE ventilation versus pressure support (ST) ventilation on objective sleep quality in stable patients with OHS. Secondary outcomes included arterial blood gases, health\u2010related quality of life, daytime sleepiness, subjective sleep quality and compliance to NIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective multicentric randomized controlled trial. Consecutive OHS patients included had daytime P<jats:sub>a<\/jats:sub>CO<jats:sub>2<\/jats:sub>\u2009&gt;\u20096\u2009kPa, BMI\u2009\u2265\u200930\u2009kg\/m<jats:sup>2<\/jats:sup>, clinical stability for more than 2\u2009weeks and were naive from home NIV. PSG were analysed centrally by two independent experts. Primary endpoint was sleep quality improvement at 2 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 69 trial patients, 60 patients had successful NIV setup. Baseline and follow\u2010up PSG were available for 26 patients randomized in the ST group and 30 in the AVAPS\u2010AE group. At baseline, P<jats:sub>a<\/jats:sub>CO<jats:sub>2<\/jats:sub> was 6.94\u2009\u00b1\u20090.71\u2009kPa in the ST group and 6.61\u2009\u00b1\u20090.71 in the AVAPS\u2010AE group (<jats:italic>P<\/jats:italic> = 0.032). No significant between\u2010group difference was observed for objective sleep quality indices. Improvement in P<jats:sub>a<\/jats:sub>CO<jats:sub>2<\/jats:sub> was similar between groups with a mean reduction of \u22120.87\u2009kPa (95% CI: \u22121.12 to \u22120.46) in the ST group versus \u22120.87\u2009kPa (95% CI: \u22121.14 to \u22120.50) in the AVAPS\u2010AE group (<jats:italic>P<\/jats:italic> = 0.984). Mean NIV use was 6.2 h per night in both groups (<jats:italic>P<\/jats:italic> = 0.93). NIV setup duration was shorter in the AVAPS\u2010AE group (<jats:italic>P<\/jats:italic> = 0.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AVAPS\u2010AE and ST ventilation for 2 months had similar impact on sleep quality and gas exchange.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13784","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T13:29:54Z","timestamp":1581600594000},"page":"1073-1081","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["AVAPS\u2010AE versus ST mode: A randomized controlled trial in patients with obesity hypoventilation syndrome"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1366-8726","authenticated-orcid":false,"given":"Maxime","family":"Patout","sequence":"first","affiliation":[{"name":"Service de Pneumologie, oncologie thoracique et Soins Intensifs Respiratoires Rouen University 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d'Angers  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4659-5076","authenticated-orcid":false,"given":"Marjolaine","family":"Georges","sequence":"additional","affiliation":[{"name":"Pulmonary Department and Respiratory Critical Care Unit University Hospital Dijon  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Perrin","sequence":"additional","affiliation":[{"name":"Service de Pneumologie H\u00f4pital de Cannes  Cannes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-6529","authenticated-orcid":false,"given":"Renaud","family":"Tamisier","sequence":"additional","affiliation":[{"name":"P\u00f4le Thorax and Vaisseaux Grenoble Alps University Hospital  Grenoble 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