{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:08:28Z","timestamp":1788455308140,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>The efficacy of combination therapy with corticosteroids and CNI, TAC and CsA, for PM\/DM\u2010ILD has been described retrospectively. However, it remains unknown which CNI treatment regimens, TAC or CsA regimens, are more effective as initial treatments for patients with PM\/DM\u2010ILD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective multicentre, open\u2010label, randomized, 52\u2010week phase 2 trial. Patients with PM\/DM\u2010ILD were randomly allocated to receive PSL plus TAC (TAC group) or PSL plus CsA (CsA group). The primary endpoint was PFS rate in the intention\u2010to\u2010treat population at 52\u2009weeks. The secondary endpoints were OS rate at 52\u2009weeks, changes in pulmonary function tests from baseline to 52\u2009weeks and AE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010eight patients were randomly assigned to the TAC group (\n                      <jats:italic>n<\/jats:italic>\n                      = 30) and the CsA group (\n                      <jats:italic>n<\/jats:italic>\n                      = 28). The PFS rates at 52\u2009weeks were 87% in the TAC group and 71% in the CsA group (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.16). The OS rates at 52\u2009weeks were 97% in the TAC group and 93% in the CsA group (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.50). The %FVC at 52\u2009weeks in the per\u2010protocol populations significantly increased in both groups. None of the patients discontinued the treatment due to AE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PSL plus TAC treatment may achieve a better short\u2010term PFS rate compared with PSL plus CsA treatment. Further studies must be conducted to evaluate the long\u2010term efficacy and safety of such treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.13978","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T22:41:20Z","timestamp":1605134480000},"page":"370-377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Prednisolone and tacrolimus versus prednisolone and cyclosporin A to treat polymyositis\/dermatomyositis\u2010associated\n                    <scp>ILD<\/scp>\n                    : A randomized, open\u2010label trial"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8809-1781","authenticated-orcid":false,"given":"Tomoyuki","family":"Fujisawa","sequence":"first","affiliation":[{"name":"Second Division, Department of Internal Medicine Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-1543","authenticated-orcid":false,"given":"Hironao","family":"Hozumi","sequence":"additional","affiliation":[{"name":"Second Division, Department of Internal Medicine Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Second Division, Department of Internal Medicine Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kaida","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Enshu Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Akamatsu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Shizuoka General Hospital  Shizuoka 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