{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:15:07Z","timestamp":1790835307081,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T00:00:00Z","timestamp":1611446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01HL095491"],"award-info":[{"award-number":["P01HL095491"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL102321"],"award-info":[{"award-number":["R01HL102321"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001222","name":"Menzies Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001222","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1053201"],"award-info":[{"award-number":["1053201"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["15SDG25890059"],"award-info":[{"award-number":["15SDG25890059"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17POST33410436"],"award-info":[{"award-number":["17POST33410436"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1RR025758\u201001"],"award-info":[{"award-number":["UL1RR025758\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Animal studies indicate that alpha\u20101 adrenergic receptor agonists and antimuscarinic agents improve genioglossus muscle activity during sleep and may be candidates for the pharmacological treatment of OSA. On the other hand, noradrenergic stimulants may be wake\u2010promoting or cause insomnia symptoms if taken before bedtime, and the addition of a medication with sedative properties, such as an antihistaminic, may reduce these side effects. In this study, we aimed to determine the effects of the combination of an alpha\u20101 adrenergic agonist (pseudoephedrine) and an antihistaminic\u2010antimuscarinic (diphenhydramine) on OSA severity (AHI), genioglossus responsiveness and other endotypic traits (V<jats:sub>passive<\/jats:sub>, muscle compensation, LG and arousal threshold).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten OSA patients performed a randomized, placebo\u2010controlled, double\u2010blind, crossover trial comparing one night of pseudoephedrine 120\u2009mg plus diphenhydramine 50\u2009mg (DAW1033D) to placebo administered prior to sleep. The AHI, genioglossus muscle responsiveness to negative oesophageal pressure and the endotypic traits were measured via PSG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The participants' median (interquartile range) age was 50 (46\u201353) years and body mass index (BMI) was 34.3 (30.6\u201339.2) kg\/m<jats:sup>2<\/jats:sup>. The drug combination had no effect on AHI (21.6 (9.1\u201349.8) on placebo vs 37.9 (5.1\u201355.4) events\/h on DAW1033D, <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.5) or genioglossus responsiveness (6.0 (2.6\u20139.2) on placebo vs 4.0 (3.5\u20137.3) %\/cm H<jats:sub>2<\/jats:sub>O). Amongst the phenotypic traits, only V<jats:sub>passive<\/jats:sub> was improved by 29 (3\u201355) % eupnoea, <jats:italic>P<\/jats:italic> =\u20090.03 (mean (95% CI)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of pseudoephedrine and diphenhydramine did not improve OSA severity or genioglossus responsiveness but induced a small improvement in upper airway collapsibility, possibly due to the decongestant effect of the medications. The results of this study do not support the use of these medications for OSA treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14009","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T04:52:52Z","timestamp":1611550372000},"page":"485-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impact of cold and flu medication on obstructive sleep apnoea and its underlying traits: A pilot randomized controlled trial"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7080-0335","authenticated-orcid":false,"given":"Luigi","family":"Taranto\u2010Montemurro","sequence":"first","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Department of Medicine and Neurology Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Sands","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Department of Medicine and Neurology Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Azarbarzin","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Department of Medicine and Neurology Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Calianese","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Department of Medicine and Neurology Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Vena","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Department of Medicine and Neurology Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Hess","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Department of Medicine and Neurology Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Department of Medicine and Neurology Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"},{"name":"Department of Otorhinolaryngology Gyeongsang National University College of Medicine and Gyeongsang National University Hospital  Jinju Republic of Korea"},{"name":"Institute of Health Sciences Gyeongsang National University  Jinju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"White","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Department of Medicine and Neurology Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wellman","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Department of Medicine and Neurology Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c110064"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/19.10.827"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00531.2013"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200605-597OC"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201209-1654OC"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201511-2172OC"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201808-1493OC"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00823-2016"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2007.07.013"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198210213071701"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.37.1.49"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.2.416"},{"key":"e_1_2_10_14_1","first-page":"41","article-title":"Differential elevation by protriptyline and depression by diazepam of upper airway respiratory motor activity","volume":"131","author":"Bonora M","year":"1985","journal-title":"Am. 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