{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:26Z","timestamp":1787016026958,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["CUHK 14113315"],"award-info":[{"award-number":["CUHK 14113315"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>We evaluated inattention and behavioural outcomes following surgery versus watchful waiting (WW) in school\u2010aged children with mild obstructive sleep apnoea (OSA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective randomized controlled study was performed in pre\u2010pubertal children aged 6\u201311\u2009years with polysomnography (PSG)\u2010confirmed mild OSA. They were assigned randomly to early surgical intervention (ES) or WW. The surgical intervention consisting of tonsillectomy with or without adenoidectomy and turbinate reduction was carried out within 4\u20136\u2009weeks after randomization. Both groups underwent PSG, attention and behavioural assessment and review by an otorhinolaryngologist at baseline and 9\u2010month follow\u2010up. The primary outcome was omission\n                      <jats:italic>T<\/jats:italic>\n                      score from Conners' continuous performance test (CPT). Secondary outcomes were parent\u2010reported behaviours, quality of life, symptoms and PSG parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 114 participants were randomized. Data of 35 subjects from the ES and 36 from the WW group were available for final analysis. No significant treatment effect could be found in all CPT parameters and behavioural outcomes. Nevertheless, significantly greater reductions were seen in PSG parameters (obstructive apnoea\u2013hypopnoea index [\u22121.4\u00a0\u00b1\u20092.0 cf. +0.3\u00a0\u00b1\u20094.1\/h,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.038] and arousal index [\u22121.3\u00a0\u00b1\u20094.4 cf. +1.4\u00a0\u00b1\u20094.5\/h,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.013]) and OSA\u201018 total symptom score (\u221217.3\u00a0\u00b1\u200919.7 cf. \u22123.6\u00a0\u00b1\u200914.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.001) in the ES group. Subjects who underwent surgery also had significantly greater weight gain (+3.3\u00a0\u00b1\u20092.1 cf. +2.2\u00a0\u00b1\u20091.5\u00a0kg,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.014) and increase in systolic blood pressure (+5.1\u00a0\u00b1\u200912.4 cf. \u22121.2\u00a0\u00b1\u20098.7\u2009mm Hg,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite improvements in PSG parameters and parent\u2010reported symptoms, surgical treatment did not lead to parallel improvements in objective attention measures in school\u2010aged children with mild OSA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.14050","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T08:13:03Z","timestamp":1617264783000},"page":"690-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effect of surgical intervention for mild childhood obstructive sleep apnoea on attention and behavioural outcomes: A randomized controlled study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0572-2777","authenticated-orcid":false,"given":"Chun T.","family":"Au","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7272-8285","authenticated-orcid":false,"given":"Kate C. C.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis L. Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel M. W.","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy S.","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun K.","family":"Wing","sequence":"additional","affiliation":[{"name":"Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert M.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.134858"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1672"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.11.003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-577OC"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201510-2099OC"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1837"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/26.8.999"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2006.05.016"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215881"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27491"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617711001743"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007343"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-1450"},{"key":"e_1_2_10_15_1","article-title":"Tonsillectomy or adenotonsillectomy versus non\u2010surgical management for obstructive sleep\u2010disordered breathing in children","volume":"14","author":"Venekamp RP","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2016.01.012"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014469800005542"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.170"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/09297049.2012.753997"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.02.001"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.3.315"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20505"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2012.10.002"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087054712461177"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-008-0205-7"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2009.02054.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2543"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.10975"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/23279095.2019.1570199"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.8.1003"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738040190070601"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139142"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3312"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.01.013"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.9.1115"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2011.07.003"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.11.060"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0591"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4976"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.07.014"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2019.07.027"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.120220"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.03.007"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.10.015"},{"key":"e_1_2_10_45_1","first-page":"233","article-title":"Urinary cysteinyl leukotriene E4 level and therapeutic response to montelukast in children with mild obstructive sleep apnea","volume":"35","author":"Sunkonkit K","year":"2017","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.17796\/1053-4625-42.6.14"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.142"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.14050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/resp.14050","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.14050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T17:48:11Z","timestamp":1692985691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.14050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/resp.14050"],"URL":"https:\/\/doi.org\/10.1111\/resp.14050","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"2020-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}