{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:28:00Z","timestamp":1790821680286,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>When home non\u2010invasive ventilation (NIV) is initiated, five goals need to be achieved: a daily use &gt;4\u00a0h\/day, an improvement in gas exchange, health\u2010related quality of life (HRQL) and sleep quality without side effects. Our aim was to assess how frequently these five goals were reached and the factors predictive of achievement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a monocentric cohort study that included patients electively established on home NIV over 2\u2009years. HRQL was assessed at baseline and follow\u2010up by the Severe Respiratory Insufficiency questionnaire. Adequate initiation was defined as the achievement of at least three of five goals and successful initiation as the achievement of all.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two\u2010hundred and fifty patients were included at baseline. NIV was initiated for: obesity hypoventilation syndrome (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200995; 38%), neuromuscular disease (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200970; 28%), chronic obstructive pulmonary disease (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200966; 26%) and chest wall disease (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200919; 8%). At follow\u2010up, measures of all five goals were available in 141 (56%) patients. NIV initiation was adequate for 96 (68%) patients and successful for 12 (9%) patients. In multivariate analysis, a tidal volume\u2009\u2265\u20097.8\u00a0ml\/kg of ideal body weight was associated with an increased likelihood of adequate NIV initiation (hazard ratio: 5.765 [95% CI:1.824\u201318.223],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.006]. Improvement in daytime partial arterial carbon dioxide pressure (PaCO\n                      <jats:sub>2<\/jats:sub>\n                      ) was not correlated to improvement in HRQL or sleep quality. Severe to very severe NIV\u2010related side effects occurred in 114 (47%) patients and were associated with higher daytime PaCO\n                      <jats:sub>2<\/jats:sub>\n                      (6.35\u2009\u00b1\u20091.08 vs. 5.92\u2009\u00b1\u20090.79\u2009kPa,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Successful home NIV initiation is rarely achieved in real life. HRQL and NIV tolerance should be assessed to improve patient\u2010centred outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.14118","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T23:56:54Z","timestamp":1627343814000},"page":"1067-1075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Defining successful non\u2010invasive ventilation initiation: Data from a real\u2010life cohort"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5931-0482","authenticated-orcid":false,"given":"Gr\u00e9goire","family":"Jolly","sequence":"first","affiliation":[{"name":"Service de Pneumologie, Oncologie Thoracique et Soins Intensifs Respiratoires Rouen University Hospital, Rouen University  Rouen 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