{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:31:04Z","timestamp":1787563864253,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>Inhalational challenge with dry mannitol powder may potentially induce cough by two mechanisms: airway bronchoconstriction or laryngeal irritation. This prospective observational study investigated laryngeal and bronchial components of cough induced by mannitol challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited consecutive patients referred for clinical mannitol challenge. The Newcastle Laryngeal Hypersensitivity Questionnaire (LHQ) was administered. Throughout testing, coughs were audio\u2010recorded to derive a cough frequency index per time and dose of mannitol. Relationships between cough indices, laryngeal hypersensitivity and bronchial hyperresponsiveness (BHR) were examined. Participants were classified by cough characteristics with k\u2010means cluster analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 90 patients who underwent challenge, 83 completed both the questionnaire and challenge. Cough frequency was greater in patients with abnormal laryngeal hypersensitivity (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.042), but not in those with BHR. There was a moderate negative correlation between coughs per minute and laryngeal hypersensitivity score (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.315,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004), with lower LHQ scores being abnormal. Cluster analysis identified an older, female\u2010predominant cluster with higher cough frequency and laryngeal hypersensitivity, and a younger, gender\u2010balanced cluster with lower cough frequency and normal laryngeal sensitivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cough frequency during mannitol challenge in our cohort reflected laryngeal hypersensitivity rather than BHR. Laryngeal hypersensitivity was more often present among older female patients. With the incorporation of cough indices, mannitol challenge may be useful to test for laryngeal hypersensitivity as well as BHR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.14165","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T01:56:37Z","timestamp":1633744597000},"page":"48-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Laryngeal hypersensitivity and abnormal cough response during mannitol bronchoprovocation challenge"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9881-9895","authenticated-orcid":false,"given":"Joy Wei\u2010Yan","family":"Lee","sequence":"first","affiliation":[{"name":"Allergy, Asthma and Clinical Immunology and Respiratory Medicine Alfred Health  Melbourne Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5729-647X","authenticated-orcid":false,"given":"Tunn Ren","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Changi General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6412-3670","authenticated-orcid":false,"given":"Brigitte M.","family":"Borg","sequence":"additional","affiliation":[{"name":"Allergy, Asthma and Clinical Immunology and Respiratory Medicine Alfred Health  Melbourne Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Sheriff","sequence":"additional","affiliation":[{"name":"Allergy, Asthma and Clinical Immunology and Respiratory Medicine Alfred Health  Melbourne Victoria 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