{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:07:25Z","timestamp":1782205645649,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["Postgraduate Scholarship"],"award-info":[{"award-number":["Postgraduate Scholarship"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001232","name":"Royal Australasian College of Physicians","doi-asserted-by":"publisher","award":["Dixon Award"],"award-info":[{"award-number":["Dixon Award"]}],"id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Right ventricular (RV) volumes are crucial outcome determinants in pulmonary diseases. Little is known about the associations of RV volumes during hospitalized acute exacerbations of chronic obstructive pulmonary disease (AECOPD). We aimed to ascertain associations of RV end\u2010diastolic volume indexed to body surface area (RVEDVI) during hospitalized AECOPD and its relationship with mortality in long\u2010term follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective observational cohort study (December 2013\u2013November 2019, ACTRN12617001562369) using dynamic retrospective ECG\u2010gated computed tomography during hospitalized AECOPD. RVEDVI was defined as normal or high using Framingham Offspring Cohort values. Cox regression determined the prognostic relevance of RVEDVI for death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 148 participants (70\u2009\u00b1\u200910\u2009years [mean\u2009\u00b1\u2009SD], 88 [59%] men) were included, of whom 75 (51%) had high RVEDVI. This was associated with more frequent hospital admissions in the 12\u2009months before admission (52\/75 [69%] vs. 38\/73 [52%], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04) and higher breathlessness (modified Medical Research Council score, 2.9\u2009\u00b1\u20091.3 vs. 2.4\u2009\u00b1\u20091.2, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007). During follow\u2010up, high RVEDVI was associated with greater mortality (log\u2010rank <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). In univariable Cox regression, increasing RVEDVI was associated with higher mortality (hazard ratio [HR]: 1.02 per ml\/m<jats:sup>2<\/jats:sup>; 95% CI: 1.01, 1.03; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). In multivariable Cox regression, RVEDVI was independently associated with mortality (HR: 1.01 per ml\/m<jats:sup>2<\/jats:sup>; 95% CI: 1.00, 1.03; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.050) at a borderline significance level. Adding RVEDVI to three COPD mortality prediction systems improved model fit (pooled chi\u2010square test [BODE: <jats:italic>p<\/jats:italic>\u00a0=\u00a00.05, ADO: <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04, DOSE: <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with hospitalized AECOPD, higher RV end\u2010diastolic volume was associated with worse acute clinical parameters and greater mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14170","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T07:10:00Z","timestamp":1635145800000},"page":"56-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Right ventricular end\u2010diastolic volume and outcomes in exacerbations of <scp>COPD<\/scp>"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7409-9328","authenticated-orcid":false,"given":"Paul","family":"Leong","sequence":"first","affiliation":[{"name":"Monash Lung and Sleep Monash Health  Clayton Victoria Australia"},{"name":"School of Clinical Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9040-8007","authenticated-orcid":false,"given":"Christian R.","family":"Osadnik","sequence":"additional","affiliation":[{"name":"Monash Lung and Sleep Monash Health  Clayton Victoria Australia"},{"name":"School of Primary and Allied Health Care Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5197-1163","authenticated-orcid":false,"given":"Paul T.","family":"King","sequence":"additional","affiliation":[{"name":"Monash Lung and Sleep Monash Health  Clayton Victoria Australia"},{"name":"School of Clinical Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1138-0590","authenticated-orcid":false,"given":"Martin I.","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Monash Lung and Sleep Monash Health  Clayton Victoria Australia"},{"name":"School of Clinical Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S.","family":"Ko","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences Monash University  Clayton Victoria Australia"},{"name":"Monash Heart Monash Health  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7424-9947","authenticated-orcid":false,"given":"Kenneth K.","family":"Lau","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences Monash University  Clayton Victoria Australia"},{"name":"Monash Imaging Monash Health  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7909-8025","authenticated-orcid":false,"given":"Simon A.","family":"Joosten","sequence":"additional","affiliation":[{"name":"Monash Lung and Sleep Monash Health  Clayton Victoria Australia"},{"name":"School of Clinical Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayan","family":"Kathriachchige","sequence":"additional","affiliation":[{"name":"Monash Lung and Sleep Monash Health  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Chua","sequence":"additional","affiliation":[{"name":"Monash Heart Monash Health  Clayton Victoria 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