{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:27:03Z","timestamp":1792650423322,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>Endosonography with intrathoracic nodal sampling is proposed as the single test with the highest granuloma detection rate in suspected sarcoidosis stage I\/II. However, most studies have been performed in limited geographical regions. Studies suggest that oesophageal endosonographic nodal sampling has higher diagnostic yield than endobronchial endosonographic nodal sampling, but a head\u2010to\u2010head comparison of both routes has never been performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Global (14 hospitals, nine countries, four continents) randomized clinical trial was conducted in consecutive patients with suspected sarcoidosis stage I\/II presenting between May 2015 and August 2017. Using an endobronchial ultrasound (EBUS) scope, patients were randomized to EBUS or endoscopic ultrasound (EUS)\u2010B\u2010guided nodal sampling, and to 22\u2010 or 25\u2010G ProCore needle aspiration (2\u2009\u00d7\u20092 factorial design). Granuloma detection rate was the primary study endpoint. Final diagnosis was based on cytology\/pathology outcomes and clinical\/radiological follow\u2010up at 6\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 358 patients were randomized: 185 patients to EBUS\u2010transbronchial needle aspiration (EBUS\u2010TBNA) and 173 to EUS\u2010B\u2010fine\u2010needle aspiration (FNA). Final diagnosis was sarcoidosis in 306 patients (86%). Granuloma detection rate was 70% (130\/185; 95% CI, 63\u201376) for EBUS\u2010TBNA and 68% (118\/173; 95% CI, 61\u201375) for EUS\u2010B\u2010FNA (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.67). Sensitivity for diagnosing sarcoidosis was 78% (129\/165; 95% CI, 71\u201384) for EBUS\u2010TBNA and 82% (115\/141; 95% CI, 74\u201387) for EUS\u2010B\u2010FNA (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.46). There was no significant difference between the two needle types in granuloma detection rate or sensitivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Granuloma detection rate of mediastinal\/hilar nodes by endosonography in patients with suspected sarcoidosis stage I\/II is high and similar for EBUS and EUS\u2010B. These findings imply that both diagnostic tests can be safely and universally used in suspected sarcoidosis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.14182","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T23:40:20Z","timestamp":1637192420000},"page":"152-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["<scp>EBUS<\/scp>\n                    versus\n                    <scp>EUS\u2010B<\/scp>\n                    for diagnosing sarcoidosis: The International Sarcoidosis Assessment (\n                    <scp>ISA<\/scp>\n                    ) randomized clinical trial"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2585-4961","authenticated-orcid":false,"given":"Laurence M. M.","family":"Crombag","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Mooij\u2010Kalverda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Szlubowski","sequence":"additional","affiliation":[{"name":"Endoscopy Unit Pulmonary Hospital  Zakopane Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Gnass","sequence":"additional","affiliation":[{"name":"Endoscopy Unit John Paul II Hospital  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt G.","family":"Tournoy","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Onze\u2010Lieve\u2010Vrouw Ziekenhuis  Aalst Belgium"},{"name":"Faculty of Medicine and Health Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Respiratory Endoscopy and Interventional Pulmonology Shanghai Chest Hospital, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6302-4534","authenticated-orcid":false,"given":"Masahide","family":"Oki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Nagoya Medical Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten K.","family":"Ninaber","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8998-2949","authenticated-orcid":false,"given":"Daniel P.","family":"Steinfort","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barton R.","family":"Jennings","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Monash Health  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moishe","family":"Liberman","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery University of Montreal, CR\u2010CHUM  Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9703-9598","authenticated-orcid":false,"given":"Semra","family":"Bilaceroglu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Health Sciences University  Izmir Turkey"},{"name":"Dr. Suat Seren Training and Research Hospital for Thoracic Medicine and Surgery Yeni\u015fehir Mahallesi  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter I.","family":"Bonta","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00ebl A.","family":"Korevaar","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1067-4696","authenticated-orcid":false,"given":"Rocco","family":"Trisolini","sequence":"additional","affiliation":[{"name":"Interventional Pulmonology Unit, Fondazione Policlinico Universitario A. 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