{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:05:53Z","timestamp":1790845553314,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201015\u2010IDEX\u201002"],"award-info":[{"award-number":["ANR\u201015\u2010IDEX\u201002"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201019\u2010P3IA\u20100003"],"award-info":[{"award-number":["ANR\u201019\u2010P3IA\u20100003"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>Case reports have suggested that continuous positive airway pressure (CPAP) telemonitoring can detect the onset of acute cardiac events such as decompensated heart failure (HF) or atrial fibrillation through an increase in the apnoea\u2013hypopnoea index (AHI) and onset of Cheyne\u2013Stokes Respiration (CSR). This study addressed whether long\u2010term remote CPAP treatment telemonitoring revealing CSR can help detect serious cardiac events (SCEs) in obstructive sleep apnoea (OSA) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This monocentric prospective cohort study included adults receiving CPAP therapy for OSA with daily telemonitoring. Any sudden increase in AHI generated an alert for the home healthcare provider to download CPAP data to identify CSR. A medical consultation was scheduled if CSR was detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 555 adults (412 men; 57% with known cardiovascular comorbidities). During the 1\u2010year follow\u2010up, 78 CSR episodes were detected in 74 patients (CSR+). The main conditions associated with incident CSR were HF (24 patients [30.8%]), ventilatory instability (21, 26.9%), leaks (13, 16.7%), medications inducing central apnoeas (baclofen, ticagrelor, opioids) (7, 9.0%), arrhythmias (6, 7.7%) and renal failure (2, 2.6%). Fifteen (20.3%) CSR+ patients had a confirmed SCE. In univariable analysis, a CSR episode increased the risk of an SCE by 13.8\u2010fold (5.7\u201335.6) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), with an adjusted OR of 5.7 (2.0\u201316.8) in multivariable analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long\u2010term telemonitoring of patients on CPAP treatment can alert CSR episodes and allows early detection of SCEs in patients with or without known cardiac comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.14192","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T21:29:51Z","timestamp":1638826191000},"page":"161-169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["<scp>CPAP<\/scp>\n                    telemonitoring can track\n                    <scp>Cheyne\u2013Stokes<\/scp>\n                    respiration and detect serious cardiac events: The\n                    <scp>AlertApn\u00e9e<\/scp>\n                    Study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6302-1130","authenticated-orcid":false,"given":"Arnaud","family":"Prigent","sequence":"first","affiliation":[{"name":"Groupe Medical de Pneumologie Polyclinique Saint\u2010Laurent  Rennes France"},{"name":"Centre du sommeil Polyclinique Saint\u2010Laurent  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Pellen","sequence":"additional","affiliation":[{"name":"SLB Pharma  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Texereau","sequence":"additional","affiliation":[{"name":"Respiratory Physiology Unit, Department of Respiratory Medicine, Cochin Hospital AP\u2010HP\/Universit\u00e9 de Paris  Paris France"},{"name":"Air Liquide Health Care VitalAire France  Gentilly France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2179-4650","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Bailly","sequence":"additional","affiliation":[{"name":"HP2 Laboratory, Inserm U1300 Univ. Grenoble Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Coquerel","sequence":"additional","affiliation":[{"name":"Service de cardiologie Polyclinique Saint Laurent  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Gervais","sequence":"additional","affiliation":[{"name":"Service de cardiologie Polyclinique Saint Laurent  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marc","family":"Liegaux","sequence":"additional","affiliation":[{"name":"Groupe Medical de Pneumologie Polyclinique Saint\u2010Laurent  Rennes France"},{"name":"Centre du sommeil Polyclinique Saint\u2010Laurent  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Luraine","sequence":"additional","affiliation":[{"name":"Groupe Medical de Pneumologie Polyclinique Saint\u2010Laurent  Rennes France"},{"name":"Centre du sommeil Polyclinique Saint\u2010Laurent  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Christophe","family":"Renaud","sequence":"additional","affiliation":[{"name":"Groupe Medical de Pneumologie Polyclinique Saint\u2010Laurent  Rennes France"},{"name":"Centre du sommeil Polyclinique Saint\u2010Laurent  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Laure","family":"Serandour","sequence":"additional","affiliation":[{"name":"SLB Pharma  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3832-2358","authenticated-orcid":false,"given":"Jean Louis","family":"P\u00e9pin","sequence":"additional","affiliation":[{"name":"HP2 Laboratory, Inserm U1300 Univ. 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