{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:18:05Z","timestamp":1770326285242,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006356","name":"Syddansk Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>The aims of this national cohort study were: (1) to evaluate mortality in patients with sarcoidosis, stratified by gender, age and systemic corticosteroid (SC) treatment and (2) to characterize comorbidities in this cohort<jats:italic>.<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with sarcoidosis from 2001 to 2015 were identified in the Danish National Patient Registry. Subgroup analyses were performed on cases treated\/not treated with SCs within 3\u2009years of the initial sarcoidosis diagnosis (as a proxy for disease severity). The Deyo\u2013Charlson Comorbidity Index was used to evaluate pre\u2010diagnostic comorbidity. Cases were matched (1:4) with controls from the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 9795 cases with sarcoidosis. Mean age was 46.5\u2009\u00b1\u200915.9\u2009years and 55% were male. The adjusted hazard ratio (HR) for death was 1.48 (95% CI 1.31\u20131.68). Mortality was higher than for controls in all age groups and in both genders. HR for death for cases treated with SCs was 1.78 (95% CI 1.49\u20132.13) and, for cases receiving no treatment, 1.24 (95% CI 1.04\u20131.48). Sarcoidosis was the most commonly registered cause of death (13.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with sarcoidosis have an increased mortality compared with matched controls. Mortality is particularly high in patients treated with SCs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14202","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:14:57Z","timestamp":1641946497000},"page":"217-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sarcoidosis\u2010related mortality and the impact of corticosteroid treatment: A population\u2010based cohort study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5061-5367","authenticated-orcid":false,"given":"Melina Gade","family":"Sikj\u00e6r","sequence":"first","affiliation":[{"name":"Department of Regional Health Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Hilberg","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Medicine Lillebaelt Hospital  Vejle Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikke","family":"Ibsen","sequence":"additional","affiliation":[{"name":"i2minds  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"L\u00f8kke","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Medicine Lillebaelt Hospital  Vejle Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00477-2016"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4081\/reumatismo.2017.965"},{"issue":"1","key":"e_1_2_10_4_1","first-page":"46","article-title":"Sarcoidosis in Denmark 1980\u20101994. A registry\u2010based incidence study comprising 5536 patients","volume":"20","author":"Byg KE","year":"2003","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1381229"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30064-X"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.105846"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcl038"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12664"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.51.3.238"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2020.1707672"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0146-2019"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01815-2017"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201010-1679OC"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.105997"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00187410"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(92)90133-8"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2004.03.012"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-11-83"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811399958"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"issue":"1","key":"e_1_2_10_25_1","first-page":"24","article-title":"The incidence, comorbidity and mortality of sarcoidosis in Korea, 2008\u20102015: a nationwide population\u2010based study","volume":"37","author":"Jeon MH","year":"2020","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-017-0076-4"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201707-564OT"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2017.09.003"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151940"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00767-2020"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41927-018-0043-6"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_10_33_1","unstructured":"Statistics Denmark.Immigrants and their descendants.2021[cited 2021 Aug 2]. 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