{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:25:18Z","timestamp":1791923118972,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Virtual bronchoscopic navigation (VBN) with fused fluoroscopy and vessel mapping provides a point of entry (POE) for puncturing airway wall to biopsy lesions. The study was designed to evaluate the safety and efficacy of this technology to diagnose peripheral pulmonary lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>It was a prospective, single\u2010arm, multicentre study. Patients underwent lesions biopsy with the Archimedes\u00ae VBN System via a POE using one of the two techniques: (1) bronchoscopic transparenchymal nodule access (BTPNA) and (2) guided transbronchial needle aspiration (TBNA). Biopsy yield, sampling yield and diagnostic yield were mainly determined in lesions biopsy attempted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and thirty patients underwent anaesthesia and constituted the intention\u2010to\u2010treat population. One hundred and four patients with 114 lesions had biopsy attempted. Mean lesion size was 2.4\u2009\u00b1\u20091.13\u2009cm. Sufficient tissue samples were obtained from 86 lesions with a biopsy yield of 75.4%. Nevertheless, sufficient samples for diagnosis based on histology\u2009\u00b1\u2009cytology were obtained from 107 lesions with a sampling yield of 93.9%. Follow\u2010up was conducted for more than 1\u00a0year, with a diagnostic yield of 75.4% and 72.8%, respectively, on high and low estimate with consideration of three lesions without follow\u2010up. Two (1.9%) pneumothoraxes and one (1.0%) mild bleeding occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BTPNA and guided TBNA contribute to safe and effective sampling of peripheral pulmonary lesions. A relatively high biopsy yield was obtained independent of the presence or absence of a bronchus sign (BS), and high sampling yield and diagnostic yield were obtained independent of location, lesion size and presence or absence of a BS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14224","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T08:17:53Z","timestamp":1645777073000},"page":"357-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Efficacy and safety of virtual bronchoscopic navigation with fused fluoroscopy and vessel mapping for access of pulmonary lesions"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3158-3256","authenticated-orcid":false,"given":"Jiayuan","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Respiratory Endoscopy, Department of Respiratory and Critical Care Medicine, Shanghai Engineering Research Center of Respiratory Endoscopy, Shanghai Chest Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard J.","family":"Criner","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine and Surgery Lewis Katz School of Medicine at Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2524-1348","authenticated-orcid":false,"given":"David","family":"Dibardino","sequence":"additional","affiliation":[{"name":"Section of Interventional Pulmonology, Pulmonary, Allergy, and Critical Care Division University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyue","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease Guangzhou Respiratory Institute  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Nader","sequence":"additional","affiliation":[{"name":"Interventional Pulmonology Cancer Treatment Center of America  Tulsa Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Lam","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Center Hong Kong Sanatorium and Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Kopas","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momen M.","family":"Wahidi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Allergy and Critical Care Medicine Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Majid","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Marron","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine and Surgery Lewis Katz School of Medicine at Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Verga","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine and Surgery Lewis Katz School of Medicine at Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix J. F.","family":"Herth","sequence":"additional","affiliation":[{"name":"Department of Pneumology and Respiratory Care Medicine, Thoraxklinik and Translational Lung Research Center University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"issue":"4","key":"e_1_2_10_2_1","first-page":"S304","article-title":"Transthoracic needle biopsy of the lung","volume":"7","author":"Dibardino DM","year":"2015","journal-title":"J Thorac Dis"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-3-201108020-00003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.4.1049"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-1764"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0637"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2708"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.54.3497"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201711-856OC"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12880-015-0060-5"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2540"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2017-0686"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206211"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2016.04.003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.145490"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201507-1332OC"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.11.013"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200612-1866OC"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201907-1292SO"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181e8b308"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.06.038"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000499"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-1010-8"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201002-0186CI"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0577"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445032"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00051-2016"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.86.6.819"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.14224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/resp.14224","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.14224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T12:30:56Z","timestamp":1692966656000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.14224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,25]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/resp.14224"],"URL":"https:\/\/doi.org\/10.1111\/resp.14224","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,25]]},"assertion":[{"value":"2021-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}