{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T15:47:13Z","timestamp":1768924033242,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Pleuroscopy with pleural biopsy has a high sensitivity for malignant pleural effusion (MPE). Because MPEs tend to recur, concurrent diagnosis and treatment of MPE during pleuroscopy is desired. However, proceeding directly to treatment at the time of pleuroscopy requires confidence in the on\u2010site diagnosis. The study's primary objective was to create a predictive model to estimate the probability of MPE during pleuroscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective observational multicentre cohort study of consecutive patients undergoing pleuroscopy was conducted. We used a logistic regression model to evaluate the probability of MPE with relation to visual assessment, rapid on\u2010site evaluation (ROSE) of touch preparation and presence of pleural nodules\/masses on computed tomography (CT). To assess the model's prediction accuracy, a bootstrapped training\/testing approach was utilized to estimate the cross\u2010validated area under the receiver operating characteristic curve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 201 patients included in the study, 103 had MPE. Logistic regression showed that higher level of malignancy on visual assessment is associated with higher odds of MPE (OR\u00a0=\u00a034.68, 95% CI\u00a0=\u00a09.17\u2013131.14,<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). The logistic regression also showed that higher level of malignancy on ROSE of touch preparation is associated with higher odds of MPE (OR\u00a0=\u00a011.63, 95% CI\u00a0=\u00a03.85\u201335.16,<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). Presence of pleural nodules\/masses on CT is associated with higher odds of MPE (OR\u00a0=\u00a06.61, 95% CI\u00a0=\u00a01.97\u201322.1,<jats:italic>p<\/jats:italic>\u00a0=\u20090.002). A multivariable logistic regression model of final pathologic status with relation to visual assessment, ROSE of touch preparation and presence of pleural nodules\/masses on CT had a cross\u2010validated AUC of 0.94 (95% CI\u00a0=\u00a00.91\u20130.97).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A prediction model using visual assessment, ROSE of touch preparation and CT scan findings demonstrated excellent predictive accuracy for MPE. Further validation studies are needed to confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14232","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T06:12:54Z","timestamp":1645164774000},"page":"350-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Predicting malignant pleural effusion during diagnostic pleuroscopy with biopsy: A prospective multicentre study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2384-4268","authenticated-orcid":false,"given":"Horiana B.","family":"Grosu","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Kern","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary And Critical Care Medicine Vanderbilt University Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6167-475X","authenticated-orcid":false,"given":"Roberto","family":"Casal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clark R.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgie","family":"Eapen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6351-5552","authenticated-orcid":false,"given":"David","family":"Ost","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frangiskos","family":"Frangopoulos","sequence":"additional","affiliation":[{"name":"Pulmonary Department Nicosia General Hospital Nicosia Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Sabath","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2590-882X","authenticated-orcid":false,"given":"Erik","family":"Vakil","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audra","family":"Schwalk","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Marcoux","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ala Eddin","family":"Sagar","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faria","family":"Nasim","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3580-3754","authenticated-orcid":false,"given":"Moiz","family":"Salahudin","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan Muhammad","family":"Arain","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Noor","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Montanez","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Mullon","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michalis","family":"Michael","sequence":"additional","affiliation":[{"name":"Cytopathology Department Nicosia General Hospital Nicosia Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilias","family":"Porfyridis","sequence":"additional","affiliation":[{"name":"Pulmonary Department Nicosia General Hospital Nicosia 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