{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:04:03Z","timestamp":1792623843431,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T00:00:00Z","timestamp":1653177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020480","name":"CSL Limited","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>\n                      Chronic obstructive pulmonary disease (COPD) is a devastating disease commonly caused by cigarette smoke (CS) exposure that drives tissue injury by persistently recruiting myeloid cells into the lungs. A significant portion of COPD patients also present with overlapping asthma pathology including eosinophilic inflammation. The \u03b2\n                      <jats:sub>c<\/jats:sub>\n                      cytokine family includes granulocyte monocyte\u2010colony\u2010stimulating factor, IL\u20105 and IL\u20103 that signal through their common receptor subunit \u03b2\n                      <jats:sub>c<\/jats:sub>\n                      to promote the expansion and survival of multiple myeloid cells including monocytes\/macrophages, neutrophils and eosinophils.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We have used our unique human \u03b2\n                      <jats:sub>c<\/jats:sub>\n                      receptor transgenic (h\u03b2\n                      <jats:sub>c<\/jats:sub>\n                      Tg) mouse strain that expresses human \u03b2\n                      <jats:sub>c<\/jats:sub>\n                      instead of mouse \u03b2\n                      <jats:sub>c<\/jats:sub>\n                      and \u03b2\n                      <jats:sub>IL3<\/jats:sub>\n                      in an acute CS exposure model. Lung tissue injury was assessed by histology and measurement of albumin and lactate dehydrogenase levels in the bronchoalveolar lavage (BAL) fluid. Transgenic mice were treated with an antibody (CSL311) that inhibits human \u03b2\n                      <jats:sub>c<\/jats:sub>\n                      signalling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      h\u03b2\n                      <jats:sub>c<\/jats:sub>\n                      Tg mice responded to acute CS exposure by expanding blood myeloid cell numbers and recruiting monocyte\u2010derived macrophages (cluster of differentiation 11b\n                      <jats:sup>+<\/jats:sup>\n                      [CD11b\n                      <jats:sup>+<\/jats:sup>\n                      ] interstitial and exudative macrophages [IM and ExM]), neutrophils and eosinophils into the lungs. This inflammatory response was associated with lung tissue injury and oedema. Importantly, CSL311 treatment in CS\u2010exposed mice markedly reduced myeloid cell numbers in the blood and BAL compartment. Furthermore, CSL311 significantly reduced lung CD11b\n                      <jats:sup>+<\/jats:sup>\n                      IM and ExM, neutrophils and eosinophils, and this decline was associated with a significant reduction in matrix metalloproteinase\u201012 (MMP\u201012) and IL\u201017A expression, tissue injury and oedema.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study identifies CSL311 as a therapeutic antibody that potently inhibits immunopathology and lung injury caused by acute CS exposure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.14297","type":"journal-article","created":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T22:54:12Z","timestamp":1653260052000},"page":"617-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Targeting the human \u03b2\n                    <sub>c<\/sub>\n                    receptor inhibits inflammatory myeloid cells and lung injury caused by acute cigarette smoke exposure"],"prefix":"10.1111","volume":"27","author":[{"given":"Nok Him","family":"Fung","sequence":"first","affiliation":[{"name":"School of Health &amp; Biomedical Sciences RMIT University  Bundoora Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Health &amp; Biomedical Sciences RMIT University  Bundoora Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8443-7071","authenticated-orcid":false,"given":"Ross","family":"Vlahos","sequence":"additional","affiliation":[{"name":"School of Health &amp; Biomedical Sciences RMIT University  Bundoora 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