{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:34:44Z","timestamp":1790861684052,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent and complex diseases that require personalized management. Although a strategy based on treatable traits (TTs) has been proposed, the prevalence and relationship of TTs to the diagnostic label and disease severity established by the attending physician in a real\u2010world setting are unknown. We assessed how the presence\/absence of specific TTs relate to the diagnosis and severity of \u2018asthma\u2019, \u2018COPD\u2019 or \u2018asthma\u2009+\u2009COPD\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors selected 30 frequently occurring TTs from the NOVELTY study cohort (NOVEL observational longiTudinal studY; NCT02760329), a large (<jats:italic>n<\/jats:italic>\u00a0=\u00a011,226), global study that systematically collects data in a real\u2010world setting, both in primary care clinics and specialized centres, for patients with \u2018asthma\u2019 (<jats:italic>n<\/jats:italic>\u00a0=\u00a05932, 52.8%), \u2018COPD\u2019 (<jats:italic>n<\/jats:italic>\u00a0=\u00a03898, 34.7%) or both (\u2018asthma\u2009+\u2009COPD\u2019; <jats:italic>n<\/jats:italic>\u00a0=\u00a01396, 12.4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results indicate that (1) the prevalence of the 30 TTs evaluated varied widely, with a mean\u2009\u00b1\u2009SD of 4.6\u2009\u00b1\u20092.6, 5.4\u2009\u00b1\u20092.6 and 6.4\u2009\u00b1\u20092.8 TTs\/patient in those with \u2018asthma\u2019, \u2018COPD\u2019 and \u2018asthma\u2009+\u2009COPD\u2019, respectively (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.0001); (2) there were no large global geographical variations, but the prevalence of TTs was different in primary versus specialized clinics; (3) several TTs were specific to the diagnosis and severity of disease, but many were not; and (4) both the presence and absence of TTs formed a pattern that is recognized by clinicians to establish a diagnosis and grade its severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results provide the largest and most granular characterization of TTs in patients with airway diseases in a real\u2010world setting to date.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14325","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T12:36:02Z","timestamp":1658406962000},"page":"929-940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Treatable traits in the NOVELTY study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3271-3788","authenticated-orcid":false,"given":"Alvar","family":"Agust\u00ed","sequence":"first","affiliation":[{"name":"C\u00e0tedra Salut Respiratoria Universitat Barcelona  Barcelona Spain"},{"name":"Servei Pneumologia, Respiratory Institute Hospital Clinic  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"CIBER Enfermedades Respiratorias  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Rapsomaniki","sequence":"additional","affiliation":[{"name":"BioPharmaceuticals Medical AstraZeneca  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0337-406X","authenticated-orcid":false,"given":"Richard","family":"Beasley","sequence":"additional","affiliation":[{"name":"Medical Research Institute of New Zealand  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod","family":"Hughes","sequence":"additional","affiliation":[{"name":"External Scientific Engagement, BioPharmaceuticals Medical AstraZeneca  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"M\u00fcllerov\u00e1","sequence":"additional","affiliation":[{"name":"Respiratory &amp; 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