{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:55:34Z","timestamp":1793386534519,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006630","name":"Lung Foundation Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006630","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>Prediction of disease course in patients with progressive pulmonary fibrosis remains challenging. The purpose of this study was to assess the prognostic value of lung fibrosis extent quantified at computed tomography (CT) using data\u2010driven texture analysis (DTA) in a large cohort of well\u2010characterized patients with idiopathic pulmonary fibrosis (IPF) enrolled in a national registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective analysis included participants in the Australian IPF Registry with available CT between 2007 and 2016. CT scans were analysed using the DTA method to quantify the extent of lung fibrosis. Demographics, longitudinal pulmonary function and quantitative CT metrics were compared using descriptive statistics. Linear mixed models, and Cox analyses adjusted for age, gender, BMI, smoking history and treatment with anti\u2010fibrotics were performed to assess the relationships between baseline DTA, pulmonary function metrics and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CT scans of 393 participants were analysed, 221 of which had available pulmonary function testing obtained within 90\u2009days of CT. Linear mixed\u2010effect modelling showed that baseline DTA score was significantly associated with annual rate of decline in forced vital capacity and diffusing capacity of carbon monoxide. In multivariable Cox proportional hazard models, greater extent of lung fibrosis was associated with poorer transplant\u2010free survival (hazard ratio [HR] 1.20,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.0001) and progression\u2010free survival (HR 1.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a multi\u2010centre observational registry of patients with IPF, the extent of fibrotic abnormality on baseline CT quantified using DTA is associated with outcomes independent of pulmonary function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.14333","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T03:45:06Z","timestamp":1658720706000},"page":"1045-1053","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Quantitative computed tomography predicts outcomes in idiopathic pulmonary fibrosis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5113-4530","authenticated-orcid":false,"given":"Stephen M.","family":"Humphries","sequence":"first","affiliation":[{"name":"Department of Radiology National Jewish Health  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5254-4144","authenticated-orcid":false,"given":"John A.","family":"Mackintosh","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"NHMRC Centre of Research Excellence in Pulmonary Fibrosis  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen E.","family":"Jo","sequence":"additional","affiliation":[{"name":"NHMRC Centre of Research Excellence in Pulmonary Fibrosis  Camperdown New South Wales Australia"},{"name":"Department of Respiratory Medicine Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon L. F.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Radiology King's College Hospital Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Silva","sequence":"additional","affiliation":[{"name":"Section of \"Scienze Radiologiche\", Department of Medicine and Surgery (DiMeC) University of Parma  Parma Italy"},{"name":"Department of Radiology University of Massachusetts Medical School, UMass Memorial Health Care  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Calandriello","sequence":"additional","affiliation":[{"name":"Dipartimento di Diagnostica per immagini, Radioterapia, Oncologia ed Ematologia Fondazione Policlinico Universitario A. Gemelli, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Chapman","sequence":"additional","affiliation":[{"name":"Respiratory Consultants  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Radiology Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Glaspole","sequence":"additional","affiliation":[{"name":"NHMRC Centre of Research Excellence in Pulmonary Fibrosis  Camperdown New South Wales Australia"},{"name":"Department of Allergy and Respiratory Medicine Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2065-4346","authenticated-orcid":false,"given":"Nicole","family":"Goh","sequence":"additional","affiliation":[{"name":"Respiratory and Sleep Medicine Austin Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6565-9928","authenticated-orcid":false,"given":"Christopher","family":"Grainge","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine John Hunter Hospital  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M. A.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Faculty of Medicine The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9979-8726","authenticated-orcid":false,"given":"Gregory J.","family":"Keir","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0777-1196","authenticated-orcid":false,"given":"Yuben","family":"Moodley","sequence":"additional","affiliation":[{"name":"School of Medicine &amp; Pharmacology University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2273-1774","authenticated-orcid":false,"given":"Paul N.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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