{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:09:13Z","timestamp":1790633353463,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Currently, computed tomography\u2010guided transthoracic biopsy (CTTB) is the most accurate diagnostic approach for pulmonary nodules suspected of malignancy. Traditional bronchoscopy has shown suboptimal diagnostic sensitivity, but the emergence of robotic\u2010assisted bronchoscopy (RAB) has the potential to improve diagnostic accuracy, maximize diagnostic yield and complete mediastinal and hilar staging in a single procedure. We aim to assess the efficacy and diagnostic performance of RAB compared to CTTB for diagnosing pulmonary nodules suspected of lung cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter retrospective review of consecutive patients who underwent RAB and CTTB for evaluating pulmonary nodules from January 2019 to March 2021 at Mayo Clinic Florida and Mayo Clinic Rochester, United States. Clinical and demographic information, nodule characteristics, outcomes and complications were compared between RAB and CTTB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 225 patients were included: 113 in the RAB group and 112 in the CTTB group. Overall diagnostic yield was 87.6% for RAB and 88.4% for CTTB. For malignant disease, RAB had a sensitivity of 82.1% and a specificity of 100%, CTTB had a sensitivity of 88.5% and a specificity of 100%. Complication rate was significantly higher for CTTB compared to RAB (17% vs. 4.4%; <jats:italic>p\u00a0=<\/jats:italic>\u00a00.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RAB, when available, can be as accurate as CTTB for sampling pulmonary nodules with similar or reduced complications and should be considered as a means for nodule biopsy, particularly when mediastinal staging is also clinically warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14368","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T02:54:42Z","timestamp":1663210482000},"page":"66-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["<scp>Robotic\u2010assisted<\/scp> bronchoscopy versus <scp>CT<\/scp>\u2010guided transthoracic biopsy for diagnosis of pulmonary nodules"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1384-6761","authenticated-orcid":false,"given":"Alejandra","family":"Yu Lee\u2010Mateus","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy, and Sleep Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8824-6691","authenticated-orcid":false,"given":"Janani","family":"Reisenauer","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Thoracic Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3769-6411","authenticated-orcid":false,"given":"Juan C.","family":"Garcia\u2010Saucedo","sequence":"additional","affiliation":[{"name":"Internal Medicine Resident, Department of Internal Medicine Morristown Medical Center  Morristown New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2064-292X","authenticated-orcid":false,"given":"David","family":"Abia\u2010Trujillo","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Sleep Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6396-3176","authenticated-orcid":false,"given":"EeeLN H.","family":"Buckarma","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Edell","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf A.","family":"Grage","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3539-4201","authenticated-orcid":false,"given":"Andrew W.","family":"Bowman","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0069-3420","authenticated-orcid":false,"given":"Gonzalo","family":"Labarca","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8866-6207","authenticated-orcid":false,"given":"Margaret M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Sleep Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5242-2385","authenticated-orcid":false,"given":"Neal M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Sleep Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3847-4127","authenticated-orcid":false,"given":"Sebastian","family":"Fernandez\u2010Bussy","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Sleep Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201505-0990OC"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0013"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2351"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8060821"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.47102\/annals-acadmedsg.V42N6p285"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2353"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4357-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1024709"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4067\/s0034-98872017000901165"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2020.03.35"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-2019-ndt-11"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-0857-z"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-2020-abpd-003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504181"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.10.016"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000782"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01693-2"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.01.036"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.08.074"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.05.534"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.54.3497"},{"issue":"4","key":"e_1_2_10_24_1","first-page":"S418","article-title":"Improved diagnostic yield of bronchoscopy in peripheral pulmonary lesions: combination of radial probe endobronchial ultrasound and rapid on\u2010site evaluation","volume":"7","author":"Chen CH","year":"2015","journal-title":"J Thorac Dis"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.08.2047"},{"key":"e_1_2_10_26_1","first-page":"A2719","article-title":"A prospective, multi\u2010center evaluation of the clinical utility of the ion Endoluminal system\u2010experience using a robotic\u2010assisted bronchoscope system with shape\u2010sensing technology","volume":"201","author":"Folch EEPM","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-1010-8"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000498951"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10235678"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000849"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.08.034"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163671"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191590"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2020.0137"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514830"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.794"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.14368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/resp.14368","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.14368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T21:28:33Z","timestamp":1692566913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.14368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,14]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/resp.14368"],"URL":"https:\/\/doi.org\/10.1111\/resp.14368","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,14]]},"assertion":[{"value":"2022-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}