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However, conflicting results have been reported on the relationship between the <jats:italic>MUC5B<\/jats:italic> minor allele and survival and it is unknown whether a specific subgroup of IPF patients might benefit from <jats:italic>MUC5B<\/jats:italic> minor allele carriage. We investigated the association between <jats:italic>MUC5B<\/jats:italic> rs35705950, survival and patient characteristics in a real\u2010world population of European IPF patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, 1751 patients with IPF from 8 European centres were included. <jats:italic>MUC5B<\/jats:italic> rs35705950 genotype, demographics, clinical characteristics at diagnosis and survival data were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a multi\u2010variate Cox proportional hazard model the <jats:italic>MUC5B<\/jats:italic> minor allele was a significant independent predictor of survival when adjusted for age, sex, high resolution computed tomography pattern, smoking behaviour and pulmonary function tests in IPF. <jats:italic>MUC5B<\/jats:italic> minor allele carriers were significantly older at diagnosis (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). The percentage of <jats:italic>MUC5B<\/jats:italic> minor allele carriers increased significantly with age from 44% in patients aged &lt;56\u2009year, to 63% in patients aged &gt;75. In IPF patients aged &lt;56, the <jats:italic>MUC5B<\/jats:italic> minor allele was not associated with survival. In IPF patients aged \u226556, survival was significantly better for <jats:italic>MUC5B<\/jats:italic> minor allele carriers (45\u2009months [CI: 42\u201349]) compared to non\u2010carriers (29\u2009months [CI: 26\u201333]; <jats:italic>p<\/jats:italic>\u00a0=\u00a04\u2009\u00d7\u200910<jats:sup>\u221212<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>MUC5B<\/jats:italic> minor allele carriage associates with a better median transplant\u2010free survival of 16\u2009months in the European IPF population aged over 56\u2009years. <jats:italic>MUC5B<\/jats:italic> genotype status might aid disease prognostication in clinical management of IPF patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14440","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T08:41:13Z","timestamp":1672044073000},"page":"455-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["<scp><i>MUC5B<\/i><\/scp> rs35705950 minor allele associates with older age and better survival in idiopathic pulmonary fibrosis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6727-8416","authenticated-orcid":false,"given":"Joanne J.","family":"van der Vis","sequence":"first","affiliation":[{"name":"St Antonius ILD Center of Excellence, Department of Pulmonology St. Antonius Hospital  Nieuwegein the Netherlands"},{"name":"St Antonius ILD Center of Excellence, Department of Clinical Chemistry St. Antonius Hospital  Nieuwegein the Netherlands"},{"name":"European Reference Network (ERN) ILD core Network center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Prasse","sequence":"additional","affiliation":[{"name":"European Reference Network (ERN) ILD core Network center"},{"name":"Division of Pulmonology Hannover Medical School &amp; DZL BREATH  Hannover Germany"},{"name":"Fraunhofer Institute ITEM  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1118-797X","authenticated-orcid":false,"given":"Elisabetta A.","family":"Renzoni","sequence":"additional","affiliation":[{"name":"Interstitial Lung Disease Unit Royal Brompton and Harefield Clinical Group, Guy's and St Thomas' NHS Foundation Trust  London UK"},{"name":"Margaret Turner Warwick Centre for Fibrosing Lung Disease National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4090-8761","authenticated-orcid":false,"given":"Carmel J. W.","family":"Stock","sequence":"additional","affiliation":[{"name":"Interstitial Lung Disease Unit Royal Brompton and Harefield Clinical Group, Guy's and St Thomas' NHS Foundation Trust  London UK"},{"name":"Margaret Turner Warwick Centre for Fibrosing Lung Disease National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canay","family":"Caliskan","sequence":"additional","affiliation":[{"name":"European Reference Network (ERN) ILD core Network center"},{"name":"Division of Pulmonology Hannover Medical School &amp; DZL BREATH  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7192-9149","authenticated-orcid":false,"given":"Toby M.","family":"Maher","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London  London UK"},{"name":"Keck Medicine of University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7579-9767","authenticated-orcid":false,"given":"Francesco","family":"Bonella","sequence":"additional","affiliation":[{"name":"European Reference Network (ERN) ILD core Network center"},{"name":"Center for Interstitial and Rare Lung Diseases, Pneumology Department Ruhrlandklinik University Hospital, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9906-0024","authenticated-orcid":false,"given":"Raphael","family":"Borie","sequence":"additional","affiliation":[{"name":"European Reference Network (ERN) ILD core Network center"},{"name":"Laboratoire d'excellence INFLAMEX Inserm U1152  Paris France"},{"name":"Service de Pneumologie A H\u00f4pital Bichat  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Crestani","sequence":"additional","affiliation":[{"name":"European Reference Network (ERN) ILD core Network center"},{"name":"Laboratoire d'excellence INFLAMEX Inserm U1152  Paris France"},{"name":"Service de Pneumologie A H\u00f4pital Bichat  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Petrek","sequence":"additional","affiliation":[{"name":"University Hospital Olomouc \u2013 Experimental Medicine  Olomouc Czech Republic"},{"name":"Faculty of Medicine and Dentistry Palacky University \u2013 Pathophysiology Molecular and Translational Medicine  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim A.","family":"Wuyts","sequence":"additional","affiliation":[{"name":"European Reference Network (ERN) ILD core Network center"},{"name":"Unit for Interstitial Lung Diseases, Department of Respiratory Medicine University Hospitals  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Wind","sequence":"additional","affiliation":[{"name":"St Antonius ILD Center of Excellence, Department of Pulmonology St. Antonius Hospital  Nieuwegein the Netherlands"},{"name":"European Reference Network (ERN) ILD core Network center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip L.","family":"Molyneaux","sequence":"additional","affiliation":[{"name":"Interstitial Lung Disease Unit Royal Brompton and Harefield Clinical Group, Guy's and St Thomas' NHS Foundation Trust  London UK"},{"name":"National Heart and Lung Institute Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan C.","family":"Grutters","sequence":"additional","affiliation":[{"name":"St Antonius ILD Center of Excellence, Department of Pulmonology St. Antonius Hospital  Nieuwegein the Netherlands"},{"name":"European Reference Network (ERN) ILD core Network center"},{"name":"Division of Heart and Lungs University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coline H. 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