{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:41:24Z","timestamp":1780076484284,"version":"3.54.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T00:00:00Z","timestamp":1673740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Device\u2010assessed activity behaviours are a novel measure for comparing intervention outcomes in patients with malignant pleural effusion (MPE). Australasian Malignant <jats:styled-content style=\"fixed-case\">PLeural<\/jats:styled-content> Effusion (AMPLE)\u20102 was a multi\u2010centre clinical trial where participants with MPE treated with an indwelling pleural catheter were randomized to daily (DD) or symptom\u2010guided (SGD) drainage for 60\u2010days. Our aim was to describe activity behaviour patterns in MPE patients, explore the impact of drainage regimen on activity behaviours and examine associations between activity behaviours and quality of life (QoL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Following randomization to DD or SGD, participants enrolled at the lead site (Perth) completed accelerometry assessment. This was repeated monthly for 5\u2010months. Activity behaviour outcomes were calculated as percent of daily waking\u2010wear time and compared between groups (Mann\u2013Whitney <jats:italic>U<\/jats:italic> test; Median [IQR]). Correlations between activity behaviour outcomes and QoL were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010one (91%) participants provided \u22651 valid accelerometry assessment (DD<jats:italic>n<\/jats:italic>\u00a0=\u00a020, SGD <jats:italic>n<\/jats:italic>\u00a0=\u00a021). Participants spent a large proportion of waking hours sedentary (72%\u201374% across timepoints), and very little time in moderate\u2010to\u2010vigorous physical activity (&lt;1% across timepoints). Compared to SGD group, DD group had a more favourable sedentary\u2010to\u2010light ratio in the week following randomization (2.4 [2.0\u20133.4] vs. 3.2 [2.4\u20136.1]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.047) and at 60\u2010days (2.0 [1.9\u20132.9] vs. 2.9 [2.8\u20136.0]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.016). Sedentary\u2010to\u2010light ratio was correlated with multiple QoL domains at multiple timepoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with MPE are largely sedentary. Preliminary results suggest that even modest differences in activity behaviours favouring the DD group could be meaningful for this clinical population. Accelerometry reflects QoL and is a useful outcome measure in MPE populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14451","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T03:24:16Z","timestamp":1673839456000},"page":"561-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Device assessed activity behaviours in patients with indwelling pleural catheter: A sub\u2010study of the Australasian Malignant <scp>PLeural<\/scp> Effusion (<scp>AMPLE<\/scp>)\u20102 randomized trial"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9913-4022","authenticated-orcid":false,"given":"Carolyn J.","family":"Peddle\u2010McIntyre","sequence":"first","affiliation":[{"name":"Exercise Medicine Research Institute Edith Cowan University  Joondalup Western Australia Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University  Joondalup 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