{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:13Z","timestamp":1787015893298,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>\n                      Respiratory muscle activity is increased in patients with chronic respiratory disease.\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG\u2010PET\/CT can assess respiratory muscle activity. We hypothesized that respiratory muscles metabolism was correlated to lung function impairment and was associated to prognosis in patients undergoing lung cancer surgery based on the research question whether respiratory muscle metabolism quantitatively correlates with the severity of lung function impairment in patients? Does respiratory muscle hypermetabolism have prognostic value?\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients undergoing\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG\u2010PET\/CT and pulmonary function tests prior to lung cancer surgery were identified. Maximum Standardized Uptake Value (SUVm) were measured in each respiratory muscle group (sternocleidomastoid, scalene, intercostal, diaphragm), normalized against deltoid SUVm. Respiratory muscle hypermetabolism was defined as SUVm &gt;90th centile in any respiratory muscle group. Clinical outcomes were collected from a prospective cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred fifty\u2010six patients were included, mostly male [110 (71%)], 53 (34%) with previous diagnosis of COPD. Respiratory muscle SUVm were: scalene: 1.84 [1.51\u20132.25], sternocleidomastoid 1.64 [1.34\u20131.95], intercostal 1.01 [0.84\u20131.16], diaphragm 1.79 [1.41\u20132.27]. Tracer uptake was inversely correlated to FEV1 for the scalene (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.29,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and SCM (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.17,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03) respiratory muscle groups and positively correlated to TLC for the scalene (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.17,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04). Respiratory muscle hypermetabolism was found in 45 patients (28.8%), who had a lower VO\n                      <jats:sub>2<\/jats:sub>\n                      max (15.4 [14.2\u201317.5] vs. 17.2\u2009mL\/kg\/min [15.2\u201321.1],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.07) and poorer overall survival when adjusting to FEV1% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings show respiratory muscle hypermetabolism is associated with lung function impairment and has prognostic significance.\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG\/PET\u2010CT should be considered as a tool for assessing respiratory muscle activity and to identify high\u2010risk patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.14475","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T03:40:51Z","timestamp":1677642051000},"page":"551-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Respiratory muscle metabolic activity on\n                    <scp>PET<\/scp>\n                    \/\n                    <scp>CT<\/scp>\n                    correlates with obstructive ventilatory defect severity and prognosis in patients undergoing lung cancer surgery"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9188-833X","authenticated-orcid":false,"given":"Kinan","family":"El Husseini","sequence":"first","affiliation":[{"name":"Service de Pneumologie, Oncologie Thoracique et Soins Intensifs Respiratoires CHU Rouen  Rouen France"},{"name":"Inserm UMRS1152 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