{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:02:57Z","timestamp":1784559777422,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Dynamic hyperinflation (DH) is a major marker of exertional dyspnoea in severe emphysema. We hypothesized that bronchoscopic lung volume reduction (BLVR) using endobronchial valves (EBVs) decreases DH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective bi\u2010centre study from both Toulouse and Limoges Hospitals, we assessed DH during an incremental cycle ergometry before and 3\u00a0months after EBVs treatment. The primary objective was to observe the change in inspiratory capacity (IC) at isotime. Target lobe volume reduction (TLVR) and changes in residual volume (RV), forced expiratory volume in one\u2010second (FEV<jats:sub>1<\/jats:sub>), mMRC, 6\u00a0minutes walking distance (6MWD), BODE and other dynamic measures like tele\u2010expiratory volume (EELV) were also analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010nine patients were included, of whom thirty\u2010eight presented DH. IC and EELV at isotime significantly improved (+214\u2009mL, <jats:italic>p<\/jats:italic>\u00a0=\u20090.004; \u2212713\u2009mL, <jats:italic>p<\/jats:italic>\u00a0\u02c2\u00a00.001, respectively). Mean changes were +177\u2009mL for FEV<jats:sub>1<\/jats:sub> (+19%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001), \u2212600\u2009mL for RV (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.0001), +33\u2009m for 6MWD (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.0001), respectively. Patients who responded on RV (&gt;430\u2009mL decrease) and FEV<jats:sub>1<\/jats:sub> (&gt;12% gain) had better improvements compared to non\u2010responders (+368\u2009mL vs. +2\u00a0mL; +398\u2009mL vs. \u221240\u2009mL IC isotime, respectively). On the opposite, in patients who responded on DH (&gt;200\u2009mL IC isotime increase), changes in TLV (\u22121216\u2009mL vs. \u2212576\u2009mL), FEV<jats:sub>1<\/jats:sub> (+261\u2009mL vs. +101\u2009mL), FVC (+496\u2009mL vs. +128\u2009mL) and RV (\u2212805\u2009mL vs. \u2212418\u2009mL) were greater compared to non\u2010responders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DH decreases after EBVs treatment, and this improvement is correlated with static changes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14488","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:16:44Z","timestamp":1678321004000},"page":"525-532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of bronchoscopic lung volume reduction with endobronchial valves on dynamic hyperinflation: Results from the <scp>PIERCE<\/scp> study"],"prefix":"10.1111","volume":"28","author":[{"given":"Romane","family":"Fumat","sequence":"first","affiliation":[{"name":"Pulmonology Department Larrey University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Pulmonology Department Larrey University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siham","family":"Mallah","sequence":"additional","affiliation":[{"name":"Pulmonology Department Larrey University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Heluain","sequence":"additional","affiliation":[{"name":"Pulmonology Department Larrey University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Favard","sequence":"additional","affiliation":[{"name":"Pulmonology Department Dupuytren University Hospital  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Simonneau","sequence":"additional","affiliation":[{"name":"Pulmonology Department Dupuytren University Hospital  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Dusselier","sequence":"additional","affiliation":[{"name":"Pulmonology Department Dupuytren University Hospital  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Barthes","sequence":"additional","affiliation":[{"name":"Pulmonology Department Larrey University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Pontier","sequence":"additional","affiliation":[{"name":"Pulmonology Department Larrey University Hospital  Toulouse 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