{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T15:26:55Z","timestamp":1748532415613,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000659","name":"Research Trainees Coordinating Centre","doi-asserted-by":"publisher","award":["2014\u201007\u2010089"],"award-info":[{"award-number":["2014\u201007\u2010089"]}],"id":[{"id":"10.13039\/501100000659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Gait speed is associated with survival in individuals with idiopathic pulmonary fibrosis (IPF). The extent to which four\u2010metre gait speed (4MGS) decline predicts adverse outcome in IPF remains unclear. We aimed to examine longitudinal 4MGS change and identify a cut\u2010point associated with adverse outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective cohort study, we recruited 132 individuals newly diagnosed with IPF and measured 4MGS change over 6\u2009months. Death\/first hospitalization at 6\u2009months were composite outcome events. Complete data (paired 4MGS plus index event) were available in 85 participants; missing 4MGS data were addressed using multiple imputation. Receiver\u2010Operating Curve plots identified a 4MGS change cut\u2010point. Cox proportional\u2010hazard regression assessed the relationship between 4MGS change and time to event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>4MGS declined over 6\u2009months (mean [95% CI] change: \u22120.05 [\u22120.09 to \u22120.01] m\/s; <jats:italic>p<\/jats:italic>\u00a0=\u20090.02). A decline of 0.07\u2009m\/s or more in 4MGS over 6\u2009months had better discrimination for the index event than change in 6\u2010minute walk distance, forced vital capacity, Composite Physiologic Index or Gender Age Physiology index. Kaplan\u2013Meier curves demonstrated a significant difference in time to event between 4MGS groups (substantial decline: &gt;\u22120.07\u2009m\/s versus minor decline\/improvers: \u2264\u22120.07\u2009m\/s; <jats:italic>p<\/jats:italic>\u00a0=\u20090.007). Those with substantial decline had an increased risk of hospitalization\/death (adjusted hazard ratio [95% CI] 4.61 [1.23\u201315.83]). Similar results were observed in multiple imputation analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In newly diagnosed IPF, a substantial 4MGS decline over 6\u2009months is associated with shorter time to hospitalization\/death at 6\u2009months. 4MGS change has potential as a surrogate endpoint for interventions aimed at modifying hospitalization\/death.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14494","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T02:43:50Z","timestamp":1679625830000},"page":"649-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Change in gait speed and adverse outcomes in patients with idiopathic pulmonary fibrosis: A prospective cohort study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9067-599X","authenticated-orcid":false,"given":"Claire 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Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Polgar","sequence":"additional","affiliation":[{"name":"Harefield Respiratory Research Group, Royal Brompton and Harefield Clinical Group Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"George","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London  London UK"},{"name":"Interstitial Lung Disease Unit Royal Brompton and Harefield Clinical Group, Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip L.","family":"Molyneaux","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London  London UK"},{"name":"Interstitial Lung Disease Unit Royal Brompton and Harefield Clinical Group, Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7192-9149","authenticated-orcid":false,"given":"Toby M.","family":"Maher","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London  London UK"},{"name":"Interstitial Lung Disease Unit Royal Brompton and Harefield Clinical Group, Guy's and St Thomas' NHS Foundation Trust  London UK"},{"name":"Keck Medicine University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Cullinan","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.\u2010C.","family":"Man","sequence":"additional","affiliation":[{"name":"Harefield Respiratory Research Group, Royal Brompton and Harefield Clinical Group Guy's and St 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