{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:25:27Z","timestamp":1792697127855,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Outside clinical trials, there is limited long\u2010term data following bronchial thermoplasty (BT). In a cohort of real\u2010world severe asthmatics in an era of biological therapy, we sought to evaluate the safety and efficacy of BT 5\u2009years post\u2010treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Every patient treated with BT at two Australian tertiary centres were recalled at 5\u2009years, and evaluated by interview and record review, Asthma Control Questionnaire (ACQ), spirometry and high\u2010resolution CT Chest. CT scans were interpreted using the modified Reiff and BRICS CT scoring systems for bronchiectasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010one patients were evaluated. At baseline, this cohort had a mean age of 59.0\u2009\u00b1\u200911.8\u2009years, mean ACQ of 3.0\u2009\u00b1\u20091.0, mean FEV1 of 55.5\u2009\u00b1\u200918.8% predicted, and 53% were receiving maintenance oral steroids in addition to triple inhaler therapy. At 5\u2009years, there was a sustained improvement in ACQ scores to 1.8\u2009\u00b1\u20091.0 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Steroid requiring exacerbation frequency was reduced from 3.8\u2009\u00b1\u20093.6 to 1.0\u2009\u00b1\u20091.6 exacerbations per annum (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). 44% of patients had been weaned off oral steroids. No change in spirometry was observed.\n                    <\/jats:p>\n                    <jats:p>\n                      CT scanning identified minor degrees of localized radiological bronchiectasis in 23\/47 patients with the modified Reiff score increasing from 0.6\u2009\u00b1\u20092.6 at baseline to 1.3\u2009\u00b1\u20092.5 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). However, no patients exhibited clinical features of bronchiectasis, such as recurrent bacterial infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sustained clinical benefit from BT at 5\u2009years was demonstrated in this cohort of very severe asthmatics. Mild, localized radiological bronchiectasis was identified in a portion of patients without clinical features of bronchiectasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.14568","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T23:28:46Z","timestamp":1691450926000},"page":"1053-1059","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Safety and efficacy of bronchial thermoplasty in\n                    <scp>Australia<\/scp>\n                    5\u2009years post\u2010procedure"],"prefix":"10.1111","volume":"28","author":[{"given":"Monica","family":"Hatch","sequence":"first","affiliation":[{"name":"Department of Thoracic Medicine Frankston Hospital, Peninsula Health  Frankston Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7449-3854","authenticated-orcid":false,"given":"Paul","family":"Lilburn","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Prince of Wales Hospital  Sydney New South Wales Australia"},{"name":"Faculty of Medicine, Health and Human Sciences Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Scott","sequence":"additional","affiliation":[{"name":"Radiology Department Frankston Hospital, Peninsula Health  Frankston Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6391-020X","authenticated-orcid":false,"given":"Alvin","family":"Ing","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6098-1766","authenticated-orcid":false,"given":"David","family":"Langton","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine Frankston Hospital, Peninsula Health  Frankston Victoria Australia"},{"name":"Faculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-204"},{"key":"e_1_2_10_3_1","unstructured":"Deloite Acess Economics.Hidden Cost of Asthma Report.2015Available from:https:\/\/d8z57tiamduo7.cloudfront.net\/resources\/the-hidden-cost-of-asthma-2015-report.pdf"},{"key":"e_1_2_10_4_1","unstructured":"PoulosLM CorrellPK ToelleBG ReddelHK MarksGB.Lung Disease in Australia Report. 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