{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:08:42Z","timestamp":1790744922760,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Persistent dyspnoea is a public health issue for which the therapeutic arsenal is limited. This study tested high\u2010flow nasal cannula therapy (HFNT) as a means to alleviate experimental dyspnoea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010two healthy subjects underwent an experimental dyspnoea induced by thoracoabdominal elastic loading. HFNT was administered with alternately FiO\n                      <jats:sub>2<\/jats:sub>\n                      of 100% (HFNT100) or 21% (HFNT21). The sensory (S\u2010VAS) and affective (A\u2010VAS) components of dyspnoea, transcutaneous CO\n                      <jats:sub>2<\/jats:sub>\n                      pressure (PtcCO\n                      <jats:sub>2<\/jats:sub>\n                      ), pulse\u2010oximetry oxygen saturation (SpO\n                      <jats:sub>2<\/jats:sub>\n                      ), heart rate, respiratory rate and skin galvanometry were monitored continuously. Three experimental sessions of 8\u2009min were conducted: the first session consisted in familiarization with the experimental dyspnoea and the next two sessions tested the effects of HFNT100 and HFNT21 alternatively in a randomized order.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HFNT21 and HFNT100 significantly reduced dyspnoea, respectively of \u2206A\u2010VAS\u2009=\u20090.80\u2009cm [\u22120.02\u20131.5];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007 and \u2206A\u2010VAS\u2009=\u20091.00\u2009cm [0.08\u20131.75];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001; \u2206S\u2010VAS\u2009=\u20090.70\u2009cm [\u22120.15\u20131.98]),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001 and \u2206S\u2010VAS\u2009=\u20090.70\u2009cm [0.08\u20131.95]),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0002) with no significant difference between HFNT21 and HFNT100. HFNT did not significantly alter the respiratory rate or the heart rate, reduced PtcCO\n                      <jats:sub>2<\/jats:sub>\n                      only on room air and GSR under both experimental conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HFNT was associated with a statistically significant reduction in the intensity of the sensory and affective components of dyspnoea, independent of oxygen addition. This relief of laboratory dyspnoea could result from a reduction of afferent\u2010reafferent mismatch.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.14580","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T10:22:23Z","timestamp":1693563743000},"page":"46-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dyspnoea relief as an inherent benefit of high flow nasal cannula therapy: A laboratory randomized trial in healthy humans"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6480-6981","authenticated-orcid":false,"given":"Clara","family":"Bianquis","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, UMRS1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique  Paris France"},{"name":"Service des Pathologies du Sommeil (D\u00e9partement \"R3S\") AP\u2010HP. Sorbonne Universit\u00e9, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Rolland\u2010Debord","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, UMRS1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique  Paris France"},{"name":"Service de Pneumologie, CHU Gabriel Montpied Universit\u00e9 Clermont Auvergne  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Rivals","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, UMRS1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique  Paris France"},{"name":"Equipe de Statistique Appliqu\u00e9e, ESPCI Paris, PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2868-9279","authenticated-orcid":false,"given":"Thomas","family":"Similowski","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, UMRS1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique  Paris France"},{"name":"D\u00e9partement \"R3S\" AP\u2010HP. 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