{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:09:22Z","timestamp":1792724962333,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A2C1006871"],"award-info":[{"award-number":["2021R1A2C1006871"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>This study aimed to evaluate the longitudinal changes in cardiopulmonary function (CPF) and identify predictors of cardiopulmonary recovery failure after lung cancer surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data was obtained from a prospective CATCH\u2010LUNG cohort study, where patients were divided into two groups based on 6\u2010min walk distance (6MWD) at baseline and 6\u2009months after surgery. CPF recovery failure was defined as a participant whose 6MWD dropped over 50\u2009m from baseline to 6\u2009months after surgery. Patients with a baseline 6MWD less than 400\u2009m were excluded. The analysis was investigated using mixed effects models, and the relative estimates for the predictors were expressed relative risk (RR) and 95% CI using a Poisson regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 419 patients, 24.1% and 17.7% showed failure of CPF recovery at 6\u2009months and 1\u2009year after surgery, respectively. In the multivariable analysis, baseline step count [RR per 1000 steps lower\u2009=\u20091.05 (95% CI, 1.01\u20131.09)], baseline dyspnoea [RR per 10 points higher\u2009=\u20091.15(1.07\u20131.23)], decreased FEV<jats:sub>1<\/jats:sub>% predicted from baseline to 2\u2009weeks after surgery [RR per 10% lower\u2009=\u20091.30(1.10\u20131.53)] and decreased moderate\u2010to\u2010vigorous physical activity (MVPA) from baseline to 2\u2009weeks [RR\u2009=\u20091.95(1.22, 3.11)] or persistent low MVPA at baseline and 2\u2009weeks after surgery [RR\u2009=\u20091.63(1.04, 2.54)] were significant factors for loss of CPF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The inability to recover CPF at 6\u2009months after surgery was linked to reduction of lung function and MVPA from baseline to 2\u2009weeks as well as baseline physical activity (PA) and dyspnoea. These results imply that engagement of perioperative PA is necessary to facilitate recovery of CPF after lung cancer surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14581","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T10:25:10Z","timestamp":1693304710000},"page":"1060-1068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Factors associated with failure of cardiopulmonary function recovery after lung cancer surgery"],"prefix":"10.1111","volume":"28","author":[{"given":"Sunga","family":"Kong","sequence":"first","affiliation":[{"name":"Patient\u2010Centered Outcomes Research Institute Samsung Medical Center  Seoul South Korea"},{"name":"Department of Clinical Research Design and Evaluation SAIHST, Sungkyunkwan University  Seoul South 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