{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:06:10Z","timestamp":1785877570844,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The acute\u2010phase protein C\u2010reactive protein (CRP) is known to be associated with poor outcomes in cancer and cardiovascular disease, but there is limited evidence of its prognostic implications in interstitial lung diseases (ILDs). We therefore set out to test whether baseline serum CRP levels are associated with mortality in four different ILDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, clinically measured CRP levels, as well as baseline demographics and lung function measures, were collected for ILD patients first presenting to the Royal Brompton Hospital between January 2010 and December 2019. Cox regression analysis was used to determine the relationship with 5\u2010year mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients included in the study were: idiopathic pulmonary fibrosis (IPF) <jats:italic>n<\/jats:italic>\u2009=\u2009422, fibrotic hypersensitivity pneumonitis (fHP) <jats:italic>n<\/jats:italic>\u2009=\u2009233, rheumatoid arthritis associated ILD (RA\u2010ILD) <jats:italic>n<\/jats:italic>\u2009=\u2009111 and Systemic Sclerosis associated ILD (SSc\u2010ILD) <jats:italic>n<\/jats:italic>\u2009=\u200986. Patients with a recent history of infection were excluded. Higher CRP levels were associated with shorter 5\u2010year survival in all four disease groups on both univariable analyses, and after adjusting for age, gender, smoking history, immunosuppressive therapy and baseline disease severity (IPF: HR (95% CI): 1.3 (1.1\u20131.5), <jats:italic>p<\/jats:italic>\u2009=\u20090.003, fHP: 1.5 (1.2\u20131.9), <jats:italic>p<\/jats:italic>\u2009=\u20090.001, RA\u2010ILD: 1.4 (1.1\u20131.84), <jats:italic>p<\/jats:italic>\u2009=\u20090.01 and SSc\u2010ILD: 2.7 (1.6\u20134.5), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher CRP levels are independently associated with reduced 5\u2010year survival in IPF, fHP, RA\u2010ILD and SSc\u2010ILD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14609","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:09:00Z","timestamp":1696223340000},"page":"228-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Serum C\u2010reactive protein is associated with earlier mortality across different interstitial lung diseases"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4090-8761","authenticated-orcid":false,"given":"Carmel J. W.","family":"Stock","sequence":"first","affiliation":[{"name":"Interstitial Lung Disease Unit, Royal Brompton and Harefield Clinical Group Guy's and St Thomas' NHS Foundation Trust  London UK"},{"name":"Margaret Turner Warwick Centre for Fibrosing Lung Disease National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Bray","sequence":"additional","affiliation":[{"name":"Interstitial Lung Disease Unit, Royal Brompton and Harefield Clinical Group Guy's and St Thomas' NHS Foundation Trust  London UK"},{"name":"Margaret Turner Warwick Centre for Fibrosing Lung Disease National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilis","family":"Kouranos","sequence":"additional","affiliation":[{"name":"Interstitial Lung Disease Unit, Royal Brompton and Harefield Clinical Group Guy's and St Thomas' NHS Foundation Trust 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Unit, Royal Brompton and Harefield Clinical Group Guy's and St Thomas' NHS Foundation Trust  London UK"},{"name":"Margaret Turner Warwick Centre for Fibrosing Lung Disease National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7845-0173","authenticated-orcid":false,"given":"Felix","family":"Chua","sequence":"additional","affiliation":[{"name":"Interstitial Lung Disease Unit, Royal Brompton and Harefield Clinical Group Guy's and St Thomas' NHS Foundation Trust  London UK"},{"name":"Margaret Turner Warwick Centre for Fibrosing Lung Disease National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2108-6248","authenticated-orcid":false,"given":"Athol U.","family":"Wells","sequence":"additional","affiliation":[{"name":"Interstitial Lung Disease Unit, Royal Brompton and Harefield Clinical Group Guy's and St Thomas' NHS Foundation Trust  London UK"},{"name":"Margaret Turner Warwick Centre for Fibrosing Lung Disease National Heart and Lung Institute, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piersante","family":"Sestini","sequence":"additional","affiliation":[{"name":"Respiratory Diseases University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1118-797X","authenticated-orcid":false,"given":"Elisabetta A.","family":"Renzoni","sequence":"additional","affiliation":[{"name":"Interstitial Lung Disease Unit, Royal Brompton and Harefield Clinical Group Guy's and St Thomas' NHS Foundation Trust  London UK"},{"name":"Margaret Turner Warwick Centre for Fibrosing Lung Disease National Heart and Lung Institute, Imperial College London  London 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