{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:48:43Z","timestamp":1782776923397,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>To evaluate the diagnostic accuracy and clinical usefulness of endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA) for mediastinal staging of centrally located T1N0M0 non\u2010small cell lung cancer (NSCLC) clinically staged with positron emission tomography\/computed tomography (PET\/CT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a study that included patients with centrally located T1N0M0 NSCLC, clinically staged with PET\/CT who underwent EBUS\u2010TBNA for mediastinal staging. Patients with negative EBUS\u2010TBNA underwent mediastinoscopy, video\u2010assisted mediastinoscopic lymphadenectomy (VAMLA) and\/or lung resection with systematic nodal dissection, that were considered the gold standard. The sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), overall accuracy of EBUS\u2010TBNA for diagnosing mediastinal metastases (N2 disease) and the number needed to treat (NNT: number of patients needed to undergo EBUS\u2010TBNA to avoid a case of pathologic N2 disease after resection) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010hundred eighteen patients were included. EBUS\u2010TBNA proved N2 disease in four patients. In the remaining 114 patients who underwent mediastinoscopy, VAMLA and\/or resection there were two cases of N2 (N2 prevalence 5.1%). The sensitivity, specificity, NPV, PPV and overall accuracy for diagnosing mediastinal metastases (N2 disease) were of 66%, 100%, 98%, 100% and 98%, respectively. The NNT was 31 (95% CI: 15\u2013119).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EBUS\u2010TBNA in patients with central clinically staged T1N0M0 NSCLC presents a good diagnostic accuracy for mediastinal staging, even in a population with low prevalence of N2 disease. Therefore, its indication should be considered in the management of even these early lung cancers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14613","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T07:15:02Z","timestamp":1698390902000},"page":"158-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["EBUS\u2010TBNA for mediastinal staging of centrally located T1N0M0 non\u2010small cell lung cancer clinically staged with PET\/CT"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6125-7358","authenticated-orcid":false,"given":"Pere","family":"Serra Mitj\u00e0","sequence":"first","affiliation":[{"name":"Pulmonology Department Hospital Universitari Germans Trias i Pujol  Badalona Barcelona 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