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We estimated the prevalence of abnormal spirometry in young Indigenous adults and determined its relationship with perinatal and early life factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used prospectively collected data from the Australian Aboriginal Birth Cohort, a birth cohort of 686 Indigenous Australian singletons. We calculated the proportion with abnormal spirometry (z\u2010score &lt;\u22121.64) and FEV<jats:sub>1<\/jats:sub> below the population mean (FEV<jats:sub>1<\/jats:sub>% predicted 0 to \u22122SD) measured in young adulthood. We evaluated the association between perinatal and early life exposures with spirometry indices using linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010nine people (39.9%, 95%CI 31.9, 48.2) had abnormal spirometry; 72 (49.3%, 95%CI 40.9, 57.7) had a FEV<jats:sub>1<\/jats:sub> below the population mean. Pre\u2010school hospitalisations for respiratory infections, younger maternal age, being overweight in early childhood and being born remotely were associated with reduced FEV<jats:sub>1<\/jats:sub> and FVC (absolute, %predicted and z\u2010score). The association between maternal age and FEV<jats:sub>1<\/jats:sub> and FVC were stronger in women, as was hospitalization for respiratory infections before age 5. Being born remotely had a stronger association with reduced FEV<jats:sub>1<\/jats:sub> and FVC in men. Participants born in a remote community were over 6 times more likely to have a FEV<jats:sub>1<\/jats:sub> below the population mean (odds ratio [OR] 6.30, 95%CI 1.93, 20.59).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Young Indigenous adults have a high prevalence of impaired lung function associated with several perinatal and early life factors, some of which are modifiable with feasible interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14639","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T17:07:46Z","timestamp":1702573666000},"page":"166-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between perinatal and early life exposures and lung function in Australian Indigenous young adults: The Aboriginal Birth Cohort study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2914-8012","authenticated-orcid":false,"given":"Vidya","family":"Navaratnam","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gardiner Hospital  Perth Western Australia Australia"},{"name":"Child Health Division, Menzies School of Health Research Charles Darwin University  Darwin Northern Territory Australia"},{"name":"Faculty of Health Science Curtin University  Perth Western Australia Australia"},{"name":"Centre for Respiratory Research University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5268-6866","authenticated-orcid":false,"given":"Douglas L.","family":"Forrester","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gardiner Hospital  Perth Western Australia Australia"},{"name":"Faculty of Health Science Curtin University  Perth Western Australia Australia"},{"name":"Centre for Respiratory Research University of Western Australia  Perth Western Australia Australia"},{"name":"Department of Respiratory Medicine Royal Darwin Hospital  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1331-3706","authenticated-orcid":false,"given":"Anne B.","family":"Chang","sequence":"additional","affiliation":[{"name":"Child Health Division, Menzies School of Health Research Charles Darwin University  Darwin Northern Territory Australia"},{"name":"Department of Respiratory Medicine Queensland Children's Hospital, Queensland University of Technology  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6063-1937","authenticated-orcid":false,"given":"Shyamali C.","family":"Dharmage","sequence":"additional","affiliation":[{"name":"Allergy and Lung 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