{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:25:06Z","timestamp":1793197506328,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T00:00:00Z","timestamp":1710633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Chronic interstitial lung disease (ILD) occurs rarely with systemic lupus erythematosus (SLE) as compared with other connective tissue diseases. This multicentric retrospective study of patients with SLE\u2010ILD from the OrphaLung and French SLE networks during 2005\u20132020 aimed to describe the characteristics of patients with SLE\u2010ILD and analyse factors associated with prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed data for 89 patients with SLE\u2010ILD (82 women, 92.1%) (median age at SLE diagnosis: 35\u2009years [interquartile range 27\u201347]). All patients met the 2019 EULAR\/ACR criteria for the diagnosis of SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty two (47.2%) patients were positive for anti\u2010ribonuclear protein antibodies and 45 (50.6%) for anti SSA\/Ro antibodies. A total of 58 (65.2%) patients had another connective tissue disease: Sj\u00f6gren's syndrome (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933, 37.1%), systemic sclerosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914, 15.7%), inflammatory myopathy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096, 6.7%), or rheumatoid arthritis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096, 6.7%). ILD was diagnosed along with SLE in 25 (28.1%) patients and at a median of 6 (0\u201314) years after the SLE diagnosis. The most frequent CT pattern was suggestive of non\u2010specific interstitial pneumonia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200941, 46.0%) with or without superimposed organizing pneumonia. After a median follow\u2010up of 86.5 [39.5\u2013161.2] months, 18 (20.2%) patients had died and 6 (6.7%) underwent lung transplantation. The median 5\u2010year and 10\u2010year transplantation\u2010free survival were 96% (92\u2013100) and 87% (78\u201397). In total, 44 (49.4%) patients showed ILD progression. Cutaneous manifestations and Raynaud's phenomenon were associated with better survival. Only forced vital capacity was significantly associated with survival and ILD progression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ILD is a rare manifestation of SLE with good overall prognosis but with possible risk of ILD progression. Patients with SLE\u2010ILD frequently have another connective tissue disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.14703","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T02:34:56Z","timestamp":1710729296000},"page":"713-721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Chronic interstitial lung disease associated with systemic lupus erythematosus: A multicentric study of 89 cases"],"prefix":"10.1111","volume":"29","author":[{"given":"Lou","family":"Deneuville","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm, PHERE, F\u201075018 Paris, et H\u00f4pital Bichat, APHP, Service de Pneumologie A, Centre constitutif du centre de r\u00e9f\u00e9rence des Maladies Pulmonaires Rares, FHU APOLLO  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Mageau","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Interne H\u00f4pital Bichat, Assistance Publique H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Pierre","family":"Debray","sequence":"additional","affiliation":[{"name":"Service de Radiologie H\u00f4pital Bichat Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-234X","authenticated-orcid":false,"given":"Karim","family":"Sacre","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Interne H\u00f4pital Bichat, Assistance Publique H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Costedoat\u2010Chalumeau","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Interne H\u00f4pital Cochin, Assistance Publique H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Hachulla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology Referral Centre for Centre for Rare Systemic Autoimmune Diseases North and North\u2010West of France (CeRAINO), CHU Lille, Univ. Lille, Inserm, U1286 \u2014 INFINITE \u2014 Institute for Translational Research in Inflammation  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurdagul","family":"Uzunhan","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, Centre constitutif du centre de r\u00e9f\u00e9rence des maladies pulmonaires rares H\u00f4pital Avicenne, INSERM U1272, Universit\u00e9 Sorbonne Paris Nord  Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5768-3159","authenticated-orcid":false,"given":"Erwan","family":"Le Tallec","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne et Immunologie Clinique CHU de Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Cadranel","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, Centre de r\u00e9f\u00e9rence des maladies pulmonaires rares (site constitutif) Assistance Publique H\u00f4pitaux de Paris\u2014H\u00f4pital Tenon et Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Marchand Adam","sequence":"additional","affiliation":[{"name":"Service de Pneumologie et explorations fonctionnelles respiratoires CHRU de Tours et universit\u00e9 de Tours, Inserm 1100  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Montani","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2013Saclay, AP\u2010HP, INSERM UMR_S 999, Service de Pneumologie et Soins Intensifs Respiratoires, H\u00f4pital de Bic\u00eatre  Le Kremlin Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"R\u00e9mi\u2010Jardin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Imaging, Heart &amp; Lung Institute University Hospital Center of Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Reynaud\u2010Gaubert","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, Centre de comp\u00e9tences des maladies pulmonaires rares CHU Nord, AP\u2010HM, Marseille; Aix\u2010 Marseille Universit\u00e9, IHU M\u00e9diterran\u00e9e Infection, MEPHI  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregoire","family":"Prevot","sequence":"additional","affiliation":[{"name":"Service de Pneumologie CHU Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Beltramo","sequence":"additional","affiliation":[{"name":"Service de Pneumologie et Soins Intensifs Respiratoires, Centre constitutif de r\u00e9f\u00e9rence des maladies pulmonaires rares CHU Dijon\u2014Bourgogne, Universit\u00e9 de Bourgogne, UMR 1231\u2014LNC\u2014HSP\u2010pathies  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Crestani","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm, PHERE, F\u201075018 Paris, et H\u00f4pital Bichat, APHP, Service de Pneumologie A, Centre constitutif du centre de r\u00e9f\u00e9rence des Maladies Pulmonaires Rares, FHU APOLLO  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5591-0955","authenticated-orcid":false,"given":"Vincent","family":"Cottin","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, Centre coordonnateur national de r\u00e9f\u00e9rence des maladies pulmonaires rares H\u00f4pital Louis Pradel, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon; 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