{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:38:19Z","timestamp":1793191099690,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015084","name":"Lung Foundation Netherlands","doi-asserted-by":"publisher","award":["5.1.17.171.0"],"award-info":[{"award-number":["5.1.17.171.0"]}],"id":[{"id":"10.13039\/501100015084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Both bronchoscopic lung volume reduction with endobronchial valves (BLVR\u2010EBV) and pulmonary rehabilitation (PR) are effective treatments for improving exercise capacity and patient\u2010reported outcomes in patients with severe Chronic Obstructive Pulmonary Disease (COPD). According to current recommendations, all BLVR\u2010EBV patients should have undergone PR first. Our aim was to study the effects of PR both before and after BLVR\u2010EBV compared to BLVR\u2010EBV alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included patients with severe COPD who were eligible for BLVR\u2010EBV and PR. Participants were randomized into three groups: PR before BLVR\u2010EBV, PR after BLVR\u2010EBV or BLVR\u2010EBV without PR. The primary outcome was change in constant work rate cycle test (CWRT) endurance time at 6\u2010month follow\u2010up of the PR groups compared to BLVR\u2010EBV alone. Secondary endpoints included changes in 6\u2010minute walking test, daily step count, dyspnoea and health\u2010related quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010seven participants were included. At 6\u2010month follow\u2010up, there was no difference in change in CWRT endurance time between the PR before BLVR\u2010EBV and BLVR\u2010EBV alone groups (median: 421 [IQR: 44; 1304] vs. 787 [123; 1024] seconds, <jats:italic>p<\/jats:italic>\u2009=\u20090.82) or in any of the secondary endpoints, but the PR after BLVR\u2010EBV group exhibited a smaller improvement in CWRT endurance time (median: 107 [IQR: 2; 573], <jats:italic>p<\/jats:italic>\u2009=\u20090.04) and health\u2010related quality of life compared to BLVR\u2010EBV alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The addition of PR to BLVR\u2010EBV did not result in increased exercise capacity, daily step count or improved patient\u2010reported outcomes compared to BLVR\u2010EBV alone, neither when PR was administered before BLVR\u2010EBV nor when PR was administered after BLVR\u2010EBV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14734","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T03:58:16Z","timestamp":1715227096000},"page":"694-703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact and timing of pulmonary rehabilitation in patients undergoing bronchoscopic lung volume reduction with endobronchial valves: A multicentre randomized controlled trial in patients with severe emphysema"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5040-4746","authenticated-orcid":false,"given":"Marieke C.","family":"van der Molen","sequence":"first","affiliation":[{"name":"Department of Pulmonary Diseases University of Groningen, University Medical Center Groningen  Groningen the Netherlands"},{"name":"Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rein","family":"Posthuma","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Maastricht University, Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"Department of Research and Development Ciro  Horn the Netherlands"},{"name":"NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-9673","authenticated-orcid":false,"given":"Jorine E.","family":"Hartman","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases University of Groningen, University Medical Center Groningen  Groningen the Netherlands"},{"name":"Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hester","family":"van der Vaart","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases University of Groningen, University Medical Center Groningen  Groningen the Netherlands"},{"name":"Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen  Groningen the Netherlands"},{"name":"Center of Rehabilitation Beatrixoord, Haren, University of Groningen University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"bij de Vaate","sequence":"additional","affiliation":[{"name":"Merem Medical Rehabilitation  Hilversum the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4136-1553","authenticated-orcid":false,"given":"Anouk W.","family":"Vaes","sequence":"additional","affiliation":[{"name":"Department of Research and Development Ciro  Horn the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"van den Borst","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Radboud Institute of Health Sciences, Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"van Ranst","sequence":"additional","affiliation":[{"name":"Pulmonary Rehabilitation Center Revant  Breda the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3822-7430","authenticated-orcid":false,"given":"Martijn A.","family":"Spruit","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Maastricht University, Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"Department of Research and Development Ciro  Horn the Netherlands"},{"name":"NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4387-4096","authenticated-orcid":false,"given":"Lowie E. 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