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We aimed to estimate the causal associations between snoring and CAD among East Asian people, and the effects\u00a0independent of BMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on 497,250 adults from China Kadoorie Biobank (CKB), we performed a conventional prospective analysis between snoring and CAD outcomes, using the multivariable Cox regression. We also leveraged genome\u2010wide association (GWAS) summary statistics of snoring and BMI from CKB (<jats:italic>n<\/jats:italic>\u2009=\u2009100,626, 47,208 snorers) and CAD outcomes from Biobank of Japan (BBJ, 5891\u201325,892 cases, 142,336\u2013168,186 controls). Single\u2010variable and multivariable two\u2010sample bi\u2010directional Mendelian randomization (MR) analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median follow\u2010up of 12.32\u2009years, 48,997 participants developed CAD. Snoring and habitual snoring were associated with incident CAD and myocardial infarction (MI), habitual snoring was also associated with stable angina pectoris (SAP). The HRs (95% CIs) of habitual snoring were 1.06 (1.04, 1.08), 1.06 (1.04, 1.08) and 1.14 (1.03, 1.25). The associations remained among non\u2010adiposity participants. Genetically predicted habitual snoring was associated with CAD and MI, the corresponding IVW\u2010ORs (95% CIs) were 1.09 (1.005, 1.19) and 1.15 (1.05, 1.25). Further adjusted BMI, habitual snoring retained independent effects on MI and CAD, and showed impact on SAP (1.09 [1.01, 1.17]). No reverse associations were observed between CADs on snoring traits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Habitual snoring elevated the risks of total CAD, MI and SAP. The causal associations were independent of BMI. These findings indicated that snoring intervention might contribute to the decrease of CAD risk among Asians.<\/jats:p><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/resp14893-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.14893","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T07:21:37Z","timestamp":1738826497000},"page":"346-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian\u00a0Randomization Study in Asia"],"prefix":"10.1111","volume":"30","author":[{"given":"Yunqing","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health Peking University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongbing","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health Peking University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7916-3870","authenticated-orcid":false,"given":"Jun","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health Peking University  Beijing China"},{"name":"Peking University Center for Public Health and Epidemic Preparedness &amp; Response  Beijing China"},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University) Ministry of Education  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianjianyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health Peking University  Beijing China"},{"name":"Peking University Center for Public Health and Epidemic Preparedness &amp; Response  Beijing China"},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University) Ministry of Education  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Pei","sequence":"additional","affiliation":[{"name":"Peking University Center for Public Health and Epidemic Preparedness &amp; Response  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Medical Research Council Population Health Research Unit University of Oxford  Oxford UK"},{"name":"Clinical Trial Service Unit &amp; Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iona Y.","family":"Millwood","sequence":"additional","affiliation":[{"name":"Medical Research Council Population Health Research Unit University of Oxford  Oxford UK"},{"name":"Clinical Trial Service Unit &amp; 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