{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:37:47Z","timestamp":1789562267593,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["DONNEL21GO"],"award-info":[{"award-number":["DONNEL21GO"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC 1449"],"award-info":[{"award-number":["CRC 1449"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>\u03b2\u2010ENaC\u2010Tg mice serve as a relevant model of muco\u2010obstructive lung disease and diffuse\u2010type emphysema, with impaired mucociliary clearance, mucus obstruction, chronic airway inflammation, structural lung damage, and altered lung function. The aim of this study was to undertake a comprehensive analysis of lung function and mechanics of the adult \u03b2\u2010ENaC\u2010Tg model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult \u03b2\u2010ENaC\u2010Tg and wild\u2010type littermates underwent X\u2010ray velocimetry (XV) scans using a Permetium XV scanner (4DMedical, Melbourne, Australia). For comparative lung mechanics, lung function assessments were conducted with a flexiVent system (SCIREQ, Montreal, Canada).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>XV imaging demonstrated elevated ventilation defect percentage, mean specific ventilation, and ventilation heterogeneity in \u03b2\u2010ENaC\u2010Tg mice. Spatial analysis of ventilation maps indicated increased ventilation variability in the peripheral lung regions, as well as an increased proportion of under\u2010ventilated areas. The flexiVent analysis indicated that compared to wild types, \u03b2\u2010ENaC\u2010Tg mice have a significantly more compliant lungs with increased inspiratory capacity, reduced tissue elastance, and increased hysteresivity (heterogeneity), suggesting loss of parenchymal integrity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This research highlights the utility of XV imaging in evaluating ventilation defects in the \u03b2\u2010ENaC\u2010Tg model and provides a comprehensive lung function analysis.<\/jats:p><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/resp70009-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.70009","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T10:33:35Z","timestamp":1741084415000},"page":"335-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Functional Lung Imaging Identifies Peripheral Ventilation Changes in \ua7b5\u2010<scp>ENaC<\/scp> Mice"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-0827","authenticated-orcid":false,"given":"Nicole","family":"Reyne","sequence":"first","affiliation":[{"name":"Robinson Research Institute, University of Adelaide  Adelaide South Australia Australia"},{"name":"Adelaide Medical School, University of Adelaide  Adelaide South Australia Australia"},{"name":"Respiratory and Sleep Medicine, Women's and Children's Hospital  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