{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:16:52Z","timestamp":1790673412564,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["19\/609"],"award-info":[{"award-number":["19\/609"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Treatable trait\u2010based personalised medicine improves outcomes in severe asthma clinics. We assessed the feasibility of a randomised controlled trial (RCT) of protocolised treatable trait\u2010guided asthma management in patients not under a severe asthma clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten week single\u2010group cohort study. Participants had a doctor's diagnosis of asthma, Asthma Control Questionnaire\u20105 (ACQ\u20105) score &gt;\u20091, and \u2265\u20091 exacerbation in the last year. Intervention: biomarker\u2010guided asthma medication according to a protocolised algorithm, targeting traits of type\u20102 inflammation and airflow obstruction. Feasibility outcomes: recruitment rates, acceptability of intervention, willingness to enrol in an RCT, need for \u2018extended\u2019 trait assessment after 10\u2009weeks, and estimation of trait prevalence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recruitment ceased with 29\/50 participants after 14\u2009months due to difficulties associated with COVID\u201019. Recruitment rate: 29\/118 (25%) of those invited to participate (95% CI 17 to 33). 24\/26 (92%) participants found the intervention acceptable and were willing to participate in a future study. After 10\u2009weeks, 65% remained not well controlled (ACQ\u20105\u2009&gt;\u20091) and would have required the \u2018extended\u2019 assessment. Participants had a mean (SD) 4.8 (2.3) of 13 traits assessed.<\/jats:p><jats:p>ACQ\u20105 improved during the study by \u22121.0 (0.3 to 1.8) units, and post\u2010bronchodilator airflow limitation reduced from 59% of participants to 35%. 12\/29 (41%) participants received continuous oral corticosteroids at some point during the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Protocolised treatable trait management was acceptable to participants, associated with significant clinical benefit, and a full RCT appears feasible. Targeting type\u20102 inflammation and airflow obstruction was insufficient to control asthma in the majority of patients, despite marked systemic corticosteroid exposure.<\/jats:p><jats:p>\n<jats:bold>Trial Registration:<\/jats:bold> ACTRN12620000935932<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.70016","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:10:01Z","timestamp":1741824601000},"page":"480-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Treatable Trait Guided Asthma Management: A Feasibility Study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9148-196X","authenticated-orcid":false,"given":"James","family":"Fingleton","sequence":"first","affiliation":[{"name":"Te Whatu Ora \u2013 Capital, Coast and Hutt Valley  Wellington New 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