{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:23:07Z","timestamp":1793762587338,"version":"4.6.1"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K08279"],"award-info":[{"award-number":["22K08279"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Interstitial lung disease (ILD) is a leading cause of morbidity and mortality in patients with systemic sclerosis (SSc). The disease course of SSc\u2010related ILD (SSc\u2010ILD) is heterogeneous, and several risk\u2010based models have been developed. This study aimed to quantitatively measure volume loss and disease extent and subsequently evaluate their associations with the development of end\u2010stage lung disease (ESLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lung volume (LV) and disease extent were retrospectively and quantitatively evaluated in two cohorts (exploratory: <jats:italic>n<\/jats:italic>\u2009=\u200970; validation: <jats:italic>n<\/jats:italic>\u2009=\u200942) using high\u2010resolution computed tomography at the time of SSc\u2010ILD diagnosis, compared to controls (<jats:italic>n<\/jats:italic>\u2009=\u200970). LV was quantitatively measured using three\u2010dimensional imaging (3D\u2010image) and standardised by predicted forced vital capacity (standardised LV). The ratio of the normally attenuated LV (range, \u2212950 to \u2212750 Hounsfield units) to the whole\u2010LV (NL%) was also measured using 3D\u2010image. The associations of these variables with ESLD were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Volume loss and normal lung area loss were noted in patients with SSc\u2010ILD compared with controls, especially in the lower lobes. Meanwhile, extended ILD lesions without volume reduction were observed in the upper lobes. Both decreased standardised LV and NL% were associated with ESLD development, and age and NL% were significant risk factors for ESLD independent of pulmonary function test parameters and standardised LV. A composite model consisting of age and NL% successfully stratified patients with SSc\u2010ILD based on the risk of ESLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>3D\u2010image may be a useful technique for assessing disease severity and predicting the risk for ESLD in patients with SSc\u2010ILD.<\/jats:p><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/resp70024-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.70024","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T10:10:07Z","timestamp":1742206207000},"page":"652-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quantitative Assessment of Systemic Sclerosis\u2013Related Interstitial Lung Disease via <scp>3D<\/scp>\u2010Imaging"],"prefix":"10.1111","volume":"30","author":[{"given":"Hiromasa","family":"Nakayasu","sequence":"first","affiliation":[{"name":"Second Division, Department of Internal Medicine Hamamatsu University School of Medicine  Hamamatsu 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