{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:17:32Z","timestamp":1771258652722,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>To evaluate the effects of a high\u2010intensity inspiratory muscle training on respiratory muscle strength, exercise capacity, dyspnoea, and health\u2010related quality of life (HRQL) in patients with pulmonary hypertension (PH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single\u2010blinded, randomised controlled trial 35 women with clinically stable PH (subgroups 1 and 4), functional class II and III, were randomly assigned to a high\u2010intensity inspiratory muscle training (IMT) or sham training. Daily 8\u2010week IMT protocol with 50% (IMT\u201050%) of maximal inspiratory muscle pressure (PImax) or sham training with a fixed load of 3 cmH<jats:sub>2<\/jats:sub>O (IMT\u2010S). Daily training time consisted of 2\u2009cycles of 30 dynamic inspiratory efforts twice daily, 7\u2009days\/week, for 8\u2009weeks using an inspiratory threshold\u2010loading device.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significantly greater improvements in the intervention group (17 patients) compared to sham (14 patients) on PImax [\u0394post\u2010pre\u2009=\u200956.4 cmH<jats:sub>2<\/jats:sub>O (95% CI 63.5 to 49.3) versus IMT\u2010S 25.2 cmH<jats:sub>2<\/jats:sub>O (95% CI 33.1 to 17.4), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001]. The intervention group improved their 6MWT [\u0394post\u2010pre, IMT 50%\u2009=\u200933.5\u2009m (95% CI 15.9 to 51.2) vs. IMT\u2010S \u22121.1\u2009m (95% CI \u221226.7 to 24.4), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001]. Dyspnoea perception at the end of the 6\u2010min walk test (6MWT) and mMRC significantly improved in the IMT\u201050% group: Dyspnoea [\u0394post\u2010pre\u2009=\u2009\u22121.1 (95% CI \u22121.5 to \u22120.7) vs. IMT\u2010S \u22120.2 (95% CI \u22121.3 to 0.9), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001] and mMRC [\u0394post\u2010pre\u2009=\u2009\u22120.6 (95% CI \u22120.8 to 0.3) vs. IMT\u2010S 0 (95% CI \u22120.2 to 0.2), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A high\u2010intensity protocol of IMT improves respiratory muscle strength, exercise capacity, and dyspnoea in symptomatic patients with PH.<\/jats:p><jats:p>\n<jats:bold>Trial Registration:<\/jats:bold> The trial was recorded on the Trials registry RBR\u201033gm3k (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/ensaiosclinicos.gov.br\/rg\/RBR-33gm3k\">https:\/\/ensaiosclinicos.gov.br\/rg\/RBR\u201033gm3k<\/jats:ext-link>)<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.70054","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T06:03:36Z","timestamp":1748239416000},"page":"760-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inspiratory Muscle Training on Exercise Capacity, Dyspnoea and Health Status in Pulmonary Hypertension: A Randomised Controlled Trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5366-6293","authenticated-orcid":false,"given":"Fabr\u00edcio Farias","family":"da Fontoura","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Ci\u00eancias Pneumologicas Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Centro de Hipertens\u00e3o Pulmonar Santa 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