{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:21:19Z","timestamp":1792120879542,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Oral corticosteroids (OCS) are the guideline recommended treatment for all asthma attacks, but benefits must be considered alongside the potential for cumulative side\u2010effects. There is interest in trialling biomarker\u2010directed management of attacks to rationalise OCS treatment in those with least benefit. Understanding stakeholder perspectives on the risks and benefits associated with OCS treatment can inform trial design and shared decision\u2010making discussions in clinical practice. The aim was to examine patients' and healthcare professionals' preferences for the risks and benefits associated with OCS treatment for asthma attacks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Discrete choice experiment (DCE) by patients with asthma and HCPs in the UK and New Zealand. Preferences were analysed using logit models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight hundred and twenty\u2010four patients and 171 HCPs completed the DCE. Avoiding the risks of permanent side effects had the greatest impact on treatment preference by patients and HCPs. Avoidance of side effects was weighted higher by patients than HCPs. Patients with uncontrolled asthma were more prepared to trade risk for benefit. Symptom recovery was the most valued clinical benefit to patients and HCPs. Patients preferred \u2018improving lung function\u2019 over \u2018avoiding additional GP treatment or hospitalisation\u2019, whereas HCPs preferred avoidance of further healthcare utilisation. Based on their responses we estimated the minimum clinically important difference for the treatment failure outcome at 20%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients and HCPs will trade\u2010off treatment benefits to avoid the side\u2010effects associated with OCS. The risk\u2013benefit balance of OCS should feature in shared decision\u2010making discussions with patients experiencing outpatient asthma attacks. The findings support developing trials to personalise acute asthma treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.70077","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T01:54:35Z","timestamp":1751334875000},"page":"1035-1045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Risk\u2013Benefit Balance of Oral Corticosteroid Treatment for Asthma Attacks: A Discrete Choice Experiment of Patients and Healthcare Professionals in the\n                    <scp>UK<\/scp>\n                    and New Zealand"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6033-0488","authenticated-orcid":false,"given":"Imran","family":"Howell","sequence":"first","affiliation":[{"name":"Respiratory Medicine Unit and Oxford Respiratory NIHR BRC, Nuffield Department of Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Noble","sequence":"additional","affiliation":[{"name":"Medical Research Institute of New Zealand  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Howell","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Unit and Oxford Respiratory NIHR BRC, Nuffield Department of Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Morgan","sequence":"additional","affiliation":[{"name":"North Bristol NHS Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Logan","sequence":"additional","affiliation":[{"name":"Gartnaval General Hospital  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Miller","sequence":"additional","affiliation":[{"name":"Patient and Public Representative  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Gartnaval General Hospital  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E. K.","family":"Russell","sequence":"additional","affiliation":[{"name":"King's Centre for Lung Health School of Immunology and Microbial Sciences, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Bafadhel","sequence":"additional","affiliation":[{"name":"King's Centre for Lung Health School of Immunology and Microbial Sciences, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0337-406X","authenticated-orcid":false,"given":"Richard","family":"Beasley","sequence":"additional","affiliation":[{"name":"Medical Research Institute of New Zealand  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-5973","authenticated-orcid":false,"given":"Ian D.","family":"Pavord","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Unit and Oxford Respiratory NIHR BRC, Nuffield Department of Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Buckell","sequence":"additional","affiliation":[{"name":"Health Economics Research Centre, Nuffield Department of Population Health University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Asthma + Lung UK \u201cFalling Into Isolation: Lived Experience of People With Severe Asthma \u201d2020."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200807\u20101126OC"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199103213241202"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/npjpcrm.2015.26"},{"key":"e_1_2_10_6_1","unstructured":"UK A \u201cDo No Harm: Safer and Better Treatment Options for People With Asthma \u201d2021."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax\u20102022\u2010219642"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000195.pub2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.51.11.1087"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(02)11679\u20105"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20102600(20)30389\u20101"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl\u20102021\u2010217325"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20102600(15)00367\u20107"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221212"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress\u20102022.4728"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta23600"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273\u2010018\u20100734\u20102"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1755\u20105345(13)70006\u2010X"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10198\u2010018\u20100954\u20106"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2012.08.2223"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00660\u20102023"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/178549"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0137\u20102019"},{"key":"e_1_2_10_24_1","unstructured":"BTS\/NICE\/SIGN \u201cAsthma: Diagnosis Monitoring and Chronic Asthma Management (Update): Evidence Reviews for Diagnostic Test Accuracy of Peak Expiratory Flow Variability for the Diagnosis of Asthma \u201d2024."},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecin.12693"},{"key":"e_1_2_10_26_1","unstructured":"Asthma Lung UK \u201cDo No Harm: Safer and Better Treatment Options for People With Asthma \u201d2021 https:\/\/www.asthma.org.uk\/support\u2010us\/campaigns\/publications\/do\u2010no\u2010harm\/#.YS9dUiUMv6Y.link."},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tra.2011.11.008"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.01.011"},{"issue":"8","key":"e_1_2_10_29_1","first-page":"639","article-title":"SMOG Grading: A New Readability Formula","volume":"12","author":"Mc Laughlin G. 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