{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T07:23:45Z","timestamp":1781076225621,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T00:00:00Z","timestamp":1752969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T00:00:00Z","timestamp":1752969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Fatigue significantly impacts quality of life in fibrosing interstitial lung diseases (fILDs). Oxyhaemoglobin desaturation contributes to fatigue in chronic obstructive pulmonary disease; however, this has not been investigated in fILD. This study aimed to elucidate the relationship between fatigue and clinical features, including oxyhaemoglobin desaturation, in fILD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants had stable fILD with exertional desaturation (SpO\n                      <jats:sub>2<\/jats:sub>\n                      \u2009\u2264\u200988% on 6\u2010min walk test, 6MWT). Univariate and multivariate analyses were performed with fatigue as the dependent variable and the clinical features related to fatigue as independent variables. Fatigue was assessed using the Fatigue Severity Scale (FSS). Independent variables were specified a priori using directed acyclic graphs based on previous studies: age, BMI, severity (FVC%), Dyspnoea\u201012 score, physical activity (mean daily steps), desaturation (nadir SpO\n                      <jats:sub>2<\/jats:sub>\n                      during 6MWT and during daily life), presence of corticosteroids, and obstructive sleep apnoea.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and sixteen participants were included with mean (SD) age of 70.9 (9.8), FVC% of 69.8 (16.1). Seventy\u2010two participants (62%) had substantial fatigue (\u2265\u200936 on FSS). Univariate analysis showed no relationship between FSS and nadir SpO\n                      <jats:sub>2<\/jats:sub>\n                      during 6MWT (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.76) or minimum SpO\n                      <jats:sub>2<\/jats:sub>\n                      during daily life (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.74). Multiple regression analyses showed associations between higher fatigue on FSS and greater breathlessness on Dyspnoea\u201012 (standardised beta\u2009=\u20090.546,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and lower daily steps (standardised beta\u2009=\u2009\u22120.188,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dyspnoea and physical activity are associated with fatigue in fILD. Exertional desaturation does not appear to contribute to fatigue in this group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      Registry (URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT03737409\">https:\/\/clinicaltrials.gov\/study\/NCT03737409<\/jats:ext-link>\n                      )\n                    <\/jats:p>\n                  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School of Translational Medicine, Monash University  Melbourne Victoria Australia"},{"name":"Institute for Breathing and Sleep  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2061-845X","authenticated-orcid":false,"given":"Anne E.","family":"Holland","sequence":"additional","affiliation":[{"name":"Respiratory Research@Alfred, School of Translational Medicine, Monash University  Melbourne Victoria Australia"},{"name":"Institute for Breathing and Sleep  Melbourne Victoria Australia"},{"name":"Department of Physiotherapy and Respiratory Medicine Alfred Health  Melbourne Victoria 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