{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:44:14Z","timestamp":1777103054043,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472082"],"award-info":[{"award-number":["82472082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302322"],"award-info":[{"award-number":["82302322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Objective<\/jats:title>\n Image\u2010guided thermal ablation (IGTA) has been increasingly used in patients with stage IA non\u2010small cell lung cancer (NSCLC) without surgical contraindications, but its long\u2010term outcomes compared to lobectomy remain unknown. This study aims to evaluate the long\u2010term outcomes of IGTA versus lobectomy and explore which patients may benefit most from ablation.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n After propensity score matching, a total of 290 patients with stage IA NSCLC between 2015 and 2023 were included. Progression\u2010free survival (PFS) and overall survival (OS) were estimated using the Kaplan\u2013Meier method. A Markov model was constructed to evaluate cost\u2010effectiveness. Finally, a radiomics model based on preoperative computed tomography (CT) was developed to perform risk stratification.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n After matching, the median follow\u2010up intervals were 34.8\u2009months for the lobectomy group and 47.2\u2009months for the ablation group. There were no significant differences between the groups in terms of 5\u2010year PFS (hazard ratio [HR], 1.83; 95% CI, 0.86\u20133.92;\n p<\/jats:italic>\n \u2009=\u20090.118) or OS (HR, 2.44; 95% CI, 0.87\u20136.63;\n p<\/jats:italic>\n \u2009=\u20090.092). In low\u2010income regions, lobectomy was not cost\u2010effective in 99% of simulations. The CT\u2010based radiomics model outperformed the traditional TNM model (AUC, 0.759 vs. 0.650;\n p<\/jats:italic>\n \u2009<\u20090.01). Moreover, disease\u2010free survival was significantly lower in the high\u2010risk group than in the low\u2010risk group (\n p<\/jats:italic>\n \u2009=\u20090.009).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study comprehensively evaluated IGTA versus lobectomy in terms of survival outcomes, cost\u2010effectiveness, and prognostic prediction. The findings suggest that IGTA may be a safe and feasible alternative to conventional surgery for carefully selected patients.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/resp.70116","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T04:35:32Z","timestamp":1756442132000},"page":"1192-1201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Outcomes Between Ablation and Lobectomy in Stage\u2009\n IA<\/scp>\n Non\u2010Small Cell Lung Cancer: A Retrospective Multicenter Study"],"prefix":"10.1111","volume":"30","author":[{"given":"Bingchen","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Sun Yat\u2010Sen University Cancer Center, Department of Minimally Invasive Intervention, Guangdong Provincial Clinical Research Center for Cancer 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