{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:39:55Z","timestamp":1792985995348,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Risk Analysis"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Evaluations of <jats:italic>Listeria monocytogenes<\/jats:italic> dose\u2010response relationships are crucially important for risk assessment and risk management, but are complicated by considerable variability across population subgroups and <jats:italic>L. monocytogenes<\/jats:italic> strains. Despite difficulties associated with the collection of adequate data from outbreak investigations or sporadic cases, the limitations of currently available animal models, and the inability to conduct human volunteer studies, some of the available data now allow refinements of the well\u2010established exponential <jats:italic>L. monocytogenes<\/jats:italic> dose response to more adequately represent extremely susceptible population subgroups and highly virulent <jats:italic>L. monocytogenes<\/jats:italic> strains. Here, a model incorporating adjustments for variability in <jats:italic>L. monocytogenes<\/jats:italic> strain virulence and host susceptibility was derived for 11 population subgroups with similar underlying comorbidities using data from multiple sources, including human surveillance and food survey data. In light of the unique inherent properties of <jats:italic>L. monocytogenes<\/jats:italic> dose response, a lognormal\u2010Poisson dose\u2010response model was chosen, and proved able to reconcile dose\u2010response relationships developed based on surveillance data with outbreak data. This model was compared to a classical beta\u2010Poisson dose\u2010response model, which was insufficiently flexible for modeling the specific case of <jats:italic>L. monocytogenes<\/jats:italic> dose\u2010response relationships, especially in outbreak situations. Overall, the modeling results suggest that most listeriosis cases are linked to the ingestion of food contaminated with medium to high concentrations of <jats:italic>L. monocytogenes<\/jats:italic>. While additional data are needed to refine the derived model and to better characterize and quantify the variability in <jats:italic>L. monocytogenes<\/jats:italic> strain virulence and individual host susceptibility, the framework derived here represents a promising approach to more adequately characterize the risk of listeriosis in highly susceptible population subgroups.<\/jats:p>","DOI":"10.1111\/risa.12235","type":"journal-article","created":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T22:49:12Z","timestamp":1403822952000},"page":"90-108","source":"Crossref","is-referenced-by-count":91,"title":["<i>Listeria monocytogenes<\/i> Dose Response Revisited\u2014Incorporating Adjustments for Variability in Strain Virulence and Host Susceptibility"],"prefix":"10.1111","volume":"35","author":[{"given":"R\u00e9gis","family":"Pouillot*","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Hoelzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherri B.","family":"Dennis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1701.P11101"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/risa.12005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9716-43-18"},{"key":"e_1_2_9_5_1","unstructured":"FDA\/FSIS.Quantitative assessment of relative risk to public health from foodborneListeria monocytogenesamong selected categories of ready\u2010to\u2010eat foods. Food and Drug Administration U.S. Department of Agriculture Centers for Disease Control and Prevention 2003. Available at:http:\/\/www.fda.gov\/Food\/FoodScienceResearch\/RiskSafetyAssessment\/ucm183966.htm Accessed March 20 2014."},{"key":"e_1_2_9_6_1","unstructured":"FAO\/WHO.Risk assessment ofListeria monocytogenesin ready to eat foods\u2014Technical report. Rome: Food and Agriculture Organization of the United Nations and World Health Organization Report No.: Microbiological Risk Assessment Series 5; 2004. Available at:http:\/\/www.fao.org\/docrep\/010\/y5394e\/y5394e00.htm Accessed March 20 2014."},{"key":"e_1_2_9_7_1","volume-title":"Quantitative Microbial Risk Assessment","author":"Haas CN","year":"1999"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/0272-4332.204048"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/risa.12006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0505.990502"},{"key":"e_1_2_9_11_1","unstructured":"FDA\/FSIS.Draft assessment of the relative risk to public health from foodborneListeria monocytogenesamong selected categories of ready\u2010to\u2010eat foods. Food and Drug Administration U.S. Department of Agriculture Centers for Disease Control and Prevention 2001."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2009.02.007"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0272-4332.2004.00440.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1539-6924.2008.01200.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2013.01.016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/420853"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00997-08"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.12.8764-8772.2005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.4315\/0362-028X-73.5.861","article-title":"Molecular and phenotypic characterization of Listeria monocytogenes from U.S. Department of Agriculture Food Safety and Inspection Service surveillance of ready\u2010to\u2010eat foods and processing facilities","volume":"73","author":"Ward TJ","year":"2010","journal-title":"Journal of Food Protection"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003087"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01293.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01146.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059852"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02626-10"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01564-10"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis268"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir902"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis269"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1701.101174"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408390903116764"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-66.4.570"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1086\/315453"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1539-6924.2008.01038.x"},{"key":"e_1_2_9_34_1","unstructured":"FAO\/WHO.Risk Assessment ofSalmonellain eggs and broiler chickens. 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