{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:38:36Z","timestamp":1769686716946,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T00:00:00Z","timestamp":1439942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FI6R 516483"],"award-info":[{"award-number":["FI6R 516483"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Risk Analysis"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>Epidemiological miner cohort data used to estimate lung cancer risks related to occupational radon exposure often lack cohort\u2010wide information on exposure to tobacco smoke, a potential confounder and important effect modifier. We have developed a method to project data on smoking habits from a case\u2010control study onto an entire cohort by means of a Monte Carlo resampling technique. As a proof of principle, this method is tested on a subcohort of 35,084 former uranium miners employed at the WISMUT company (Germany), with 461 lung cancer deaths in the follow\u2010up period 1955\u20131998. After applying the proposed imputation technique, a biologically\u2010based carcinogenesis model is employed to analyze the cohort's lung cancer mortality data. A sensitivity analysis based on a set of 200 independent projections with subsequent model analyses yields narrow distributions of the free model parameters, indicating that parameter values are relatively stable and independent of individual projections. This technique thus offers a possibility to account for unknown smoking habits, enabling us to unravel risks related to radon, to smoking, and to the combination of both.<\/jats:p>","DOI":"10.1111\/risa.12472","type":"journal-article","created":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T05:26:19Z","timestamp":1439961979000},"page":"954-967","source":"Crossref","is-referenced-by-count":2,"title":["Modeling Lung Carcinogenesis in Radon\u2010Exposed Miner Cohorts: Accounting for Missing Information on Smoking"],"prefix":"10.1111","volume":"36","author":[{"given":"Teun","family":"van Dillen","sequence":"first","affiliation":[{"name":"Centre for Environmental Safety and Security National Institute for Public Health and the Environment (RIVM)  Bilthoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fieke","family":"Dekkers","sequence":"additional","affiliation":[{"name":"Centre for Environmental Safety and Security National Institute for Public Health and the Environment (RIVM)  Bilthoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harmen","family":"Bijwaard","sequence":"additional","affiliation":[{"name":"Centre for Environmental Safety and Security National Institute for Public Health and the Environment (RIVM)  Bilthoven The Netherlands"},{"name":"Medical Technology Research Group Inholland University of Applied Sciences  Haarlem The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Br\u00fcske","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen German Research Center for Environmental Health  Neuherberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010Erich","family":"Wichmann","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen German Research Center for Environmental Health  Neuherberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Kreuzer","sequence":"additional","affiliation":[{"name":"Department of Radiation Protection and Health Federal Office for Radiation Protection  Neuherberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Grosche","sequence":"additional","affiliation":[{"name":"Department of Radiation Protection and Health Federal Office for Radiation Protection  Neuherberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,19]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Health Effects of Exposure to Radon (BEIR VI)","author":"National Research Council, Committee on Health Risks of Exposure to Radon","year":"1999"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyp216"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603403"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/HP.0b013e3181cd669d"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR1803.1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR2102.1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HP.0000252259.72683.2a"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HP.0b013e3181b8ce81"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR2377.1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rpd\/ncq469"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1620"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25834"},{"key":"e_1_2_9_14_1","first-page":"S1","article-title":"Special issue. The impact of the reduction in tobacco smoking on U.S. lung cancer mortality (1975\u20132000): Collective results from the Cancer Intervention and Surveillance Modeling Network (CISNET)","volume":"32","year":"2012","journal-title":"Risk Analysis"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00411-012-0423-z"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-200207000-00003"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/rpd\/ncn119"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HP.0000175443.08832.84"},{"key":"e_1_2_9_19_1","volume-title":"Fall\u2010Kontroll\u2010Studie bei ehemaligen Besch\u00e4ftigten der \u2018WISMUT\u2019","author":"Br\u00fcske\u2010Hohlfeld I","year":"2004"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000071410.26053.c4"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001215)"},{"key":"e_1_2_9_22_1","unstructured":"HarrisMD LeenhoutsHP Uijt de HaagPAM. A Two\u2010Mutation Model of Carcinogenesis: Application to Lung Tumours Using Rat Experimental Data. RIVM Report 610065006. Bilthoven: National Institute for Public Health and the Environment (RIVM) 1998. Available at:http:\/\/www.rivm.nl\/bibliotheek\/rapporten\/610065006.html."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.rpd.a006780"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1088\/0952-4746\/14\/2\/002"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00411-004-0247-6"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004110050138"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004110000084"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi345"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00411-007-0109-0"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116398"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1539-6924.1990.tb01053.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199305000-00004"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553000110085797"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1667\/0033-7587(2001)1560078:AOAHCO2.0.CO;2"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00411-003-0213-8"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph10030963"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/rpd\/ncr048"}],"container-title":["Risk Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Frisa.12472","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/risa.12472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T19:55:13Z","timestamp":1696017313000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/risa.12472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,19]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/risa.12472"],"URL":"https:\/\/doi.org\/10.1111\/risa.12472","archive":["Portico"],"relation":{},"ISSN":["0272-4332","1539-6924"],"issn-type":[{"value":"0272-4332","type":"print"},{"value":"1539-6924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,19]]}}}