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The model explicitly considered personal hygiene practices by food handlers as well as their activities and simulated a spatially explicit dynamic system representing complex interaction patterns among food handlers, facility environment, and foods. To demonstrate the utility of the model in a decision\u2010making context, we created a hypothetical case study and used it to compare different risk mitigation strategies for reducing contamination and spread of <jats:italic>Listeria monocytogenes<\/jats:italic> in a food facility. Model results indicated that areas with no direct contact with foods (e.g., loading dock and restroom) can serve as contamination niches and recontaminate areas that have direct contact with food products. Furthermore, food handlers\u2019 behaviors, including, for example, hygiene and sanitation practices, can impact the persistence of microbial contamination in the facility environment and the spread of contamination to prepared foods. Using this case study, we also demonstrated benefits of an ABM framework for addressing food safety in a complex system in which emergent system\u2010level responses are predicted using a bottom\u2010up approach that observes individual agents (e.g., food handlers) and their behaviors. Our model can be applied to a wide variety of pathogens, food commodities, and activity patterns to evaluate efficacy of food\u2010safety management practices and quantify contamination reductions associated with proposed mitigation strategies in food facilities.<\/jats:p>","DOI":"10.1111\/risa.13215","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T19:50:32Z","timestamp":1539633032000},"page":"992-1021","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["An Agent\u2010Based Model for Pathogen Persistence and Cross\u2010Contamination Dynamics in a Food Facility"],"prefix":"10.1111","volume":"39","author":[{"given":"Amir","family":"Mokhtari","sequence":"first","affiliation":[{"name":"Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Analytics and Outreach  College Park MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane M.","family":"Van Doren","sequence":"additional","affiliation":[{"name":"Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Analytics and Outreach  College Park MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cosrev.2017.03.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-52.10.688"},{"key":"e_1_2_6_4_1","unstructured":"Almond Board of California. 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