{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:57:10Z","timestamp":1785891430467,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Risk Analysis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Benchmark dose (BMD) methodology has been employed as a default dose\u2013response modeling approach to determine the toxicity value of chemicals to support regulatory chemical risk assessment. Especially, a relatively standardized BMD analysis framework has been established for modeling toxicological data regarding the formats of input data, dose\u2013response models, definitions of benchmark response, and model uncertainty consideration. However, the BMD approach has not been well developed for epidemiological data mainly because of the diverse designs of epidemiological studies and various formats of data reported in the literature. Although most of the epidemiological BMD analyses were developed to solve a particular question, the methods proposed in two recent studies are able to handle cohort and case\u2013control studies using summary data with consideration of adjustments for confounders. Therefore, the purpose of the present study is to investigate and compare the \u201ceffective count\u201d\u2010based BMD modeling approach and adjusted relative risk (RR)\u2010based BMD analysis approach to identify an appropriate BMD modeling framework that can be generalized for analyzing published data of prospective cohort studies for BMD analysis. The two methods were applied to the same set of studies that investigated the association between bladder and lung cancer and inorganic arsenic exposure for BMD estimation. The results suggest that estimated BMDs and BMDLs are relatively consistent; however, with the consideration of established common practice in BMD analysis, modeling adjusted RR values as continuous data for BMD estimation is a more generalizable approach harmonized with the BMD approach using toxicological data.<\/jats:p>","DOI":"10.1111\/risa.14196","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T07:40:28Z","timestamp":1690443628000},"page":"743-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Benchmark dose modeling for epidemiological dose\u2013response assessment using prospective cohort studies"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8395-7833","authenticated-orcid":false,"given":"Francesco","family":"De Pretis","sequence":"first","affiliation":[{"name":"Department of Environmental and Occupational Health School of Public Health Indiana University Bloomington Bloomington Indiana USA"},{"name":"Department of Communication and Economics University of Modena and Reggio Emilia Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1945-5876","authenticated-orcid":false,"given":"Yun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health School of Public Health Indiana University Bloomington Bloomington Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6245-4505","authenticated-orcid":false,"given":"Pengcheng","family":"Xun","sequence":"additional","affiliation":[{"name":"Department of Global Value Access and Outcomes Atara Biotherapeutics Inc. Thousand Oaks California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5512-2377","authenticated-orcid":false,"given":"Kan","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health School of Public Health Indiana University Bloomington Bloomington Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106111"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105810"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10623"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559325819863634"},{"key":"e_1_2_7_6_1","unstructured":"Bogen K. T. Chen C. L. &Tsuji J. S.(2014).Significant nonlinearity of lung cancer risk in relation to arsenic in drinking water in northeastern Taiwan.Society of Toxicology 53rd Annual Meeting Phoenix AZ(Poster)."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.16.4.504"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2009.08.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.epi\u201009\u20100333"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2105\/ajph.94.5.741"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.5.411"},{"issue":"6","key":"e_1_2_7_12_1","first-page":"1296","article-title":"Incidence of internal cancers and ingested inorganic arsenic: A seven\u2010year follow\u2010up study in Taiwan","volume":"55","author":"Chiou H. Y.","year":"1995","journal-title":"Cancer Research"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10934529.2013.823329"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph2006030039"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2012.11.007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272\u20100590(84)90107\u20106"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2298\/aadm161015019d"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138182"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010008\u20109146\u20105"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.05.083"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph121214990"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.152768"},{"key":"e_1_2_7_23_1","volume-title":"Modern epidemiology","author":"Lash T. L.","year":"2021"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2017.04.008"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108655"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr265"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476\u2010069x\u201013\u201044"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010013\u20100220\u20102"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp1289"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.152752"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.51936\/uwah2960"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2014.01.004"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408444.2019.1573804"},{"key":"e_1_2_7_34_1","volume-title":"Benchmark dose technical guidance","author":"US Environmental Protection Agency. Risk Assessment Forum","year":"2012"},{"key":"e_1_2_7_35_1","volume-title":"Arsenic in rice and rice products risk assessment report","author":"US Food and Drug Administration (US FDA)","year":"2016"},{"key":"e_1_2_7_36_1","volume-title":"Econometric analysis of count data","author":"Winkelmann R.","year":"2008"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115439"}],"container-title":["Risk Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/risa.14196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T10:59:50Z","timestamp":1712314790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/risa.14196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,27]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/risa.14196"],"URL":"https:\/\/doi.org\/10.1111\/risa.14196","archive":["Portico"],"relation":{},"ISSN":["0272-4332","1539-6924"],"issn-type":[{"value":"0272-4332","type":"print"},{"value":"1539-6924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,27]]},"assertion":[{"value":"2022-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}