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The present work aimed at assessing the adequacy of the 20% default value often attributed to this factor while accounting for concomitant inhalation exposure to the reference concentration (RfC). Steady\u2010state toxicokinetic equations were applied to calculate constant blood concentration (Cblood\n                    <jats:sub>ss<\/jats:sub>\n                    ) in adults and 1\u20133\u2010year\u2010old children for 12 volatile organic compounds (VOCs). Three exposure scenarios were considered for each compound, namely, (1) ingestion of the reference dose (RfD) alone; (2) inhalation of the RfC alone; and (3) ingestion of 20% of the RfD combined with inhalation of the RfC. Using Monte Carlo simulations, probabilistic ratios of Cblood\n                    <jats:sub>ss<\/jats:sub>\n                    were computed for Scenario 3 over Scenario 1. Ratios &gt;1, demonstrating an exceedance of the RfD\u2010equivalent Cblood\n                    <jats:sub>ss<\/jats:sub>\n                    by Scenario 3, are obtained at mean and 97.5\n                    <jats:sup>th<\/jats:sup>\n                    percentile value for eight of the chosen VOCs in adults, with range of 0.3\u201329 at the mean and of 0.32\u201352 at the 97.5\n                    <jats:sup>th<\/jats:sup>\n                    percentile. Nine VOCs exhibited such exceedance in children (ranges: 0.34\u201336 at the mean; 0.38\u201357 at the 97.5\n                    <jats:sup>th<\/jats:sup>\n                    percentile). For eight VOCs, ratios &gt;1 were mainly explained by high RfC\u2010related intake as compared to RfD\u2010related intake. Concluding, steady\u2010state toxicokinetic modeling was successfully used to illustrate the importance of other media's guidance levels\u2010related exposures, in the present case the RfC, to evaluate the magnitude of the relative source contribution factor required when determining health\u2010based guidance values for chemicals in drinking water.\n                  <\/jats:p>","DOI":"10.1111\/risa.70362","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:40:25Z","timestamp":1789706425000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Probabilistic Assessment of the Relative Source Contribution Factor While Accounting for Exposure to Other Regulated Media: A Toxicokinetic Proof\u2010of\u2010Concept for Volatile Drinking Water Contaminants"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5384-0877","authenticated-orcid":false,"given":"Mathieu","family":"Valcke","sequence":"first","affiliation":[{"name":"Direction de la sant\u00e9 environnementale, au travail et de la toxicologie Institut national de sant\u00e9 publique du Qu\u00e9bec (INSPQ)  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"D\u00e9partement de sant\u00e9 environnementale et sant\u00e9 au travail \u00c9cole de sant\u00e9 publique de l'Universit\u00e9 de Montr\u00e9al (ESPUM)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2018.03.009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(03)00030-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-04721-8"},{"key":"e_1_2_8_5_1","volume-title":"Drinking Water and Health","author":"National Research Council (U.S.)","year":"1977"},{"key":"e_1_2_8_6_1","unstructured":"CalEPA.2008.Technical Supporting Document for Noncancer RELs Appendix D3.California Environmental Protection Agency (CalEPA)."},{"key":"e_1_2_8_7_1","volume-title":"Protocole d\u2019\u00e9laboration de Recommandations pour La Qualit\u00e9 Des Sols En Fonction de L'environnement et De La Sant\u00e9 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