{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:01:10Z","timestamp":1779289270761,"version":"3.51.4"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We describe a new class of dose finding methods to be used in early phase clinical trials. Under some added parametric conditions the class reduces to the family of continual reassessment method (CRM) designs. Under some relaxation of the underlying structure the method is equivalent to the cumulative cohort design, the modified toxicity probability interval method or Bayesian optimal interval design classes of methods, which are non-parametric in nature whereas the CRM class can be viewed as being strongly parametric. The class proposed is characterized as being semiparametric since it corresponds to the CRM with a nuisance parameter. Performance is good, matching that of the CRM class and improving on it in some cases. The structure allows theoretical questions to be more easily investigated and to understand better how different classes of methods relate to one another.<\/jats:p>","DOI":"10.1111\/rssb.12229","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T09:08:04Z","timestamp":1489050484000},"page":"1487-1508","source":"Crossref","is-referenced-by-count":47,"title":["Semiparametric Dose Finding Methods"],"prefix":"10.1093","volume":"79","author":[{"given":"M.","family":"Clertant","sequence":"first","affiliation":[{"name":"Universit\u00e9 Pierre et Marie Curie , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"O\u2019Quigley","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Pierre et Marie Curie , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"key":"2023022002193031600_rssb12229-cit-0001","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.spl.2012.01.026","article-title":"A note on the robustness of the continual reassessment method","volume":"82","author":"Azriel","year":"2012","journal-title":"Statist. Probab. Lett."},{"key":"2023022002193031600_rssb12229-cit-0002","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1016\/j.jspi.2011.03.001","article-title":"The treatment versus experimentation dilemma in dose finding studies","volume":"141","author":"Azriel","year":"2011","journal-title":"J. Statist. Planng Inf."},{"key":"2023022002193031600_rssb12229-cit-0003","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/(SICI)1097-0258(19980530)17:10<1103::AID-SIM793>3.0.CO;2-9","article-title":"Cancer phase I clinical trials: efficient dose escalation with overdose control","volume":"17","author":"Babb","year":"1998","journal-title":"Statist. Med."},{"key":"2023022002193031600_rssb12229-cit-0004","volume-title":"Semiparametric inference and models","author":"Bickel","year":"2005"},{"key":"2023022002193031600_rssb12229-cit-0005","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/biomet\/92.4.863","article-title":"Coherence principles in dose-finding studies","volume":"92","author":"Cheung","year":"2005","journal-title":"Biometrika"},{"key":"2023022002193031600_rssb12229-cit-0050","volume-title":"dfcrm: dose-finding by the continual reassessment method.","author":"Cheung","year":"2013"},{"key":"2023022002193031600_rssb12229-cit-0006","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.0006-341X.2002.00671.x","article-title":"A simple technique to evaluate model sensitivity in the continual reassessment method","volume":"58","author":"Cheung","year":"2002","journal-title":"Biometrics"},{"key":"2023022002193031600_rssb12229-cit-0007","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1016\/j.jspi.2006.07.009","article-title":"Cumulative cohort design for dose-finding","volume":"137","author":"Ivanova","year":"2007","journal-title":"J. Statist. Planng Inf."},{"key":"2023022002193031600_rssb12229-cit-0008","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1177\/1740774510382799","article-title":"A modified toxicity probability interval method for dose-finding trials","volume":"7","author":"Ji","year":"2010","journal-title":"Clin. Trials"},{"key":"2023022002193031600_rssb12229-cit-0009","first-page":"507","article-title":"Bayesian optimal interval designs for phase I clinical trials","volume":"64","author":"Liu","year":"2015","journal-title":"Appl. Statist."},{"key":"2023022002193031600_rssb12229-cit-0011","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/biostatistics\/3.1.51","article-title":"Non-parametric optimal design in dose finding studies","volume":"3","author":"O\u2019Quigley","year":"2002","journal-title":"Biostatistics"},{"key":"2023022002193031600_rssb12229-cit-0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2307\/2531628","article-title":"Continual reassessment method: a practical design for phase 1 clinical trials in cancer","volume":"46","author":"O\u2019Quigley","year":"1990","journal-title":"Biometrics"},{"key":"2023022002193031600_rssb12229-cit-0012","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2307\/2532905","article-title":"Continual reassessment method: a likelihood approach","volume":"52","author":"O\u2019Quigley","year":"1996","journal-title":"Biometrics"},{"key":"2023022002193031600_rssb12229-cit-0013","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/biomet\/83.2.395","article-title":"Consistency of continual reassessment method under model misspecification","volume":"83","author":"Shen","year":"1996","journal-title":"Biometrika"},{"key":"2023022002193031600_rssb12229-cit-0014","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1200\/JCO.2007.12.7712","article-title":"Shortening the timeline of pediatric phase I trials: the rolling six design","volume":"26","author":"Skolnik","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"2023022002193031600_rssb12229-cit-0015","doi-asserted-by":"crossref","first-page":"925","DOI":"10.2307\/2531693","article-title":"Design and analysis of phase i clinical trials","author":"Storer","year":"1989","journal-title":"Biometrics"},{"key":"2023022002193031600_rssb12229-cit-0016","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.spl.2016.02.019","article-title":"A note on continual reassessment method","volume":"113","author":"Tian","year":"2016","journal-title":"Statist. Probab. Lett."}],"container-title":["Journal of the Royal Statistical Society Series B: Statistical Methodology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Frssb.12229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jrsssb\/article-pdf\/79\/5\/1487\/49269262\/jrsssb_79_5_1487.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jrsssb\/article-pdf\/79\/5\/1487\/49269262\/jrsssb_79_5_1487.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T02:20:36Z","timestamp":1676859636000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jrsssb\/article\/79\/5\/1487\/7041078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,9]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,3,9]]},"published-print":{"date-parts":[[2017,11,1]]}},"URL":"https:\/\/doi.org\/10.1111\/rssb.12229","relation":{},"ISSN":["1369-7412","1467-9868"],"issn-type":[{"value":"1369-7412","type":"print"},{"value":"1467-9868","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,11]]},"published":{"date-parts":[[2017,3,9]]}}}