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This is in contrast with the common claim that the inverse of the observed Fisher information is a better approximation of the variance of the maximum likelihood estimator. Observed Fisher information cannot be known a priori; however, if an experiment is conducted sequentially, in a series of runs, the observed Fisher information from previous runs is known. In the current work, two adaptive designs are proposed that use the observed Fisher information from previous runs to inform the design of future runs.<\/jats:p>","DOI":"10.1111\/rssb.12378","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T07:31:07Z","timestamp":1592206267000},"page":"1029-1058","source":"Crossref","is-referenced-by-count":5,"title":["Adaptive Designs for Optimal Observed Fisher Information"],"prefix":"10.1093","volume":"82","author":[{"given":"Adam","family":"Lane","sequence":"first","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center \u00a0 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"2023022408364989800_","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jspi.2012.09.012","article-title":"Elemental information matrices and optimal experimental designs for generalized regression models","volume":"144","author":"Atkinson","year":"2014","journal-title":"J. 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