{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:11:31Z","timestamp":1791389491847,"version":"4.3.3"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T00:00:00Z","timestamp":1459987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["106657"],"award-info":[{"award-number":["106657"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["97577"],"award-info":[{"award-number":["97577"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["25116"],"award-info":[{"award-number":["25116"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate salivary characteristics, such as flow rate, buffering capacity and amylase activity, and associate these parameters with oral health in individuals with Moebius syndrome (MS) and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The researchers assessed caries (ICDAS), periodontal disease (PSR), and plaque (Silness L\u00f6e) indexes in both groups. Unstimulated, stimulated, and bilateral parotid saliva were also collected. The salivary flow (milliliters\/minute) and \u03b1\u2010amylase activity were measured in all samples. The \u03b1\u2010amylase activity was determined by maltose production. The buffering capacity was measured in stimulated saliva by titration of 0.01N HCl.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The occurrence of carious lesions, related to cut\u2010off 2, as well as the occurrence of periodontal disease, was significantly higher (<jats:italic>p<\/jats:italic> &gt; 0.05) in participants with MS when compared to the control group. Also, MS individuals presented decreased salivary flow, decreased buffering capacity, and amylase activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MS individuals present salivary alterations, which can be related to higher risk for caries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12175","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T17:05:10Z","timestamp":1460307910000},"page":"265-270","source":"Crossref","is-referenced-by-count":15,"title":["Salivary parameters and oral health in the Moebius syndrome"],"prefix":"10.1111","volume":"36","author":[{"given":"Maria Carolina","family":"Martins Mussi","sequence":"first","affiliation":[{"name":"Researcher, Department of Oral Pathology and Special Patients School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Moffa","sequence":"additional","affiliation":[{"name":"Professor, Ceuma University  Maranh\u00e3o Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talita","family":"Castro","sequence":"additional","affiliation":[{"name":"PhD student, Department of Oral Pathology and Special Patients, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Lira Ortega","sequence":"additional","affiliation":[{"name":"Postdoctoral researcher, Department of Oral Pathology and Special Patients School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Freitas","sequence":"additional","affiliation":[{"name":"Undergraduate student, Department of Oral Pathology and Special Patients School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Braga","sequence":"additional","affiliation":[{"name":"Professor, Department of Pediatric Dentistry School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter L.","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Professor, Department of Biochemistry Schulich School of Medicine and Dentistry University of Western Ontario  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Helena","family":"Cury Gallottini","sequence":"additional","affiliation":[{"name":"Professor, Department of Oral Pathology and Special Patients School of Dentistry University of S\u00e3o aulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.27.2.122"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470230"},{"key":"e_1_2_7_4_1","first-page":"461","article-title":"Gestational hyperthermia as a possible cause for Moebius syndrome","volume":"37","author":"Graham JM","year":"1988","journal-title":"Teratology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81934-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2006.00649.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)12363-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806253382604"},{"key":"e_1_2_7_9_1","first-page":"315","article-title":"Is misoprostol teratogenic? 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