{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T13:52:27Z","timestamp":1777297947778,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aimed to investigate the level of salivary endothelin\u20101 in premalignant and malignant lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this study, 75 cases were investigated of which 25 cases were healthy, 25 cases had oral lichen planus (OLP), and 25 cases had oral squamous cell carcinoma (OSCC). In order to collect the saliva samples, the unstimulated spitting was used. The samples were collected between 9 and 12 a.m. They were sent to the lab shortly after being collected and salivary endothelin\u20101 was recorded for each sample according to the instruction of factory by using enzyme\u2010linked immunosorbent assay and optical density at a wavelength of 450 nm. SPSS version 20 and one\u2010way ANOVA and LSD tests were used to analyze the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean of salivary endothelin\u20101 level in patients with OSCC was 163.98 pg\/ml, in patients with OLP was 160.9 pg\/ml, and in healthy people was 137.19 pg\/ml. The analysis of one\u2010way ANOVA suggested that the level of salivary endothelin\u20101 in both groups was the same and significantly higher than that in control group (<jats:italic>p<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The level of salivary endothelin\u20101 in patients with SCC and OLP was higher than that in healthy group. Thus, it can be used as the latest therapeutic protocol for oral premalignant and malignant lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12217","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T14:16:57Z","timestamp":1487168217000},"page":"134-139","source":"Crossref","is-referenced-by-count":5,"title":["Investigating the level of salivary endothelin\u20101 in premalignant and malignant lesions"],"prefix":"10.1111","volume":"37","author":[{"given":"Tahereh","family":"Nosratzehi","sequence":"first","affiliation":[{"name":"Assistant Professor Oral and Dental Diease Research Center, Department of Oral Medicine Faculty of Dentistry Zahedan University of Medical Sciences  Zahedan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirous","family":"Risbaf Fakour","sequence":"additional","affiliation":[{"name":"Assistant Professor Oral and Dental Disease Research Center Department of Oral and Maxillofacial Surgery Faculty of Dentistry, Zahedan University of Medical Sciences  Zahedan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebrahim","family":"Alijani","sequence":"additional","affiliation":[{"name":"Assistant Professor Clinical Immunology Research Center and Department of Immunology Faculty of Medicine Zahedan University of Medical Sciences  Zahedan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Salehi","sequence":"additional","affiliation":[{"name":"Dentist Zahedan University of Medical Sciences  Zahedan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.118677"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.06.015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2010.08.006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.20205"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(78)90383-3"},{"key":"e_1_2_10_7_1","unstructured":"GreenbergMS GlickM.Burket's oral medicine: diagnosis & treatment: PMPH\u2010USA; 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