{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:51:29Z","timestamp":1789775489103,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003810","name":"Hospital de Cl\u00ednicas de Porto Alegre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the relationship between salivary secretory immunoglobulin A (sIgA) concentration and dental caries in children with Down syndrome (DS) and compare it with findings in non\u2010DS children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The sample comprised 61 DS children and 52 non\u2010DS children, aged 6 to 14 years. Caries experience, plaque index (PI), and gingival bleeding index (GBI) were recorded. Saliva samples were collected from all children. Total salivary sIgA concentrations were determined using an enzymatic assay method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Caries experience in primary and permanent dentitions were similar in DS and non\u2010DS children. However, PI and GBI values were significantly lower in DS compared to non\u2010DS children. DS children had higher salivary sIgA concentrations compared to non\u2010DS children. No difference in sIgA concentration was observed between children with and without caries experience in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DS children have higher salivary sIgA concentrations than non\u2010DS children. However, this finding did not correlate with caries experience in the study population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/scd.12222","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T13:56:41Z","timestamp":1488808601000},"page":"115-119","source":"Crossref","is-referenced-by-count":16,"title":["Salivary secretory IgA concentration and dental caries in children with Down syndrome"],"prefix":"10.1111","volume":"37","author":[{"given":"Lina N.","family":"Hashizume","sequence":"first","affiliation":[{"name":"Department of Preventive and Social Dentistry Faculty of Dentistry Federal University of Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Schwertner","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Dentistry Faculty of Dentistry Federal University of Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio Jos\u00e9 Santos","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Dentistry Faculty of Dentistry Federal University of Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Simon","family":"Coitinho","sequence":"additional","affiliation":[{"name":"Department of Microbiology Immunology and Parasitology Institute of Basic Health Sciences Federal University of Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia Schuler","family":"Faccini","sequence":"additional","affiliation":[{"name":"Genetic Medical Service Hospital de Cl\u00ednicas de Porto Alegre  Porto Alegre Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2012(09)04"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/8.1.35"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5037.2012.00545.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.2012.00297.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2005.06.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322011000700010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-5712(98)00030-X"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.2005.tb01405.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3104\/reports.2022"},{"key":"e_1_2_8_11_1","first-page":"279","article-title":"The relationship between dental caries in the primary dentition and anti S. mutans serum antibodies in children with Down's syndrome","volume":"19","author":"Morinushi T","year":"1995","journal-title":"J Clin Pediatr Dent"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2004.00457.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(82)90086-3"},{"key":"e_1_2_8_14_1","first-page":"216","article-title":"Antibodies to indigenous and laboratory strains of Streptococcus mutans in saliva from children with dental caries and from caries\u2010free children","volume":"9","author":"Riviere GR","year":"1987","journal-title":"Pediatr Dent"},{"key":"e_1_2_8_15_1","first-page":"272","article-title":"IgA antibodies to Streptococcus mutans in caries\u2010resistant and \u2010susceptible children","volume":"16","author":"Rose PT","year":"1994","journal-title":"Pediatr Dent"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016490"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.9.5675-5684.2005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1128\/iai.61.5.1964-1971.1993","article-title":"Protective salivary immunoglobulin A responses against Streptococcus mutans infection after intranasal immunization with S. mutans antigen I\/II coupled to the B subunit of cholera toxin","volume":"61","author":"Katz J","year":"1993","journal-title":"Infect Immun"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-4388.84681"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2016.03.005"},{"key":"e_1_2_8_21_1","unstructured":"World Health Organization.Declaration of Helsinki. 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