{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:38:40Z","timestamp":1763642320556},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Leukocyte adhesion defect I is a rare disorder (1:1,000,000) caused by diminished expression of CD\u201018 \u03b22 integrins on leukocytes leading to abnormal adhesion, migration, and chemotaxis. Clinical manifestations include delayed separation of umbilical cord, omphalitis, recurrent severe infections, impaired wound healing, persistent oral ulcers, and severe periodontitis in primary and permanent dentition.<\/jats:p><jats:p>A 5\u2010year\u2010old girl, second\u2010born child to parents with consanguinity, presented with pain and mobility of lower teeth. There was history of recurrent infections and multiple hospital admissions with CD18 level\u20103% and frame shift mutation in ITGB2, on 21q22.3. There were scars on hands and feet. Oral examination revealed multiple missing teeth and periodontitis in primary dentition. Oral prophylaxis and palliative treatments were performed with periodic follow\u2010ups.<\/jats:p><jats:p>Interdisciplinary care is ubiquitous for patients with immune deficiencies. Early consultation with pediatric dentists and exploration of medical history is essential for diagnosis and treatment of rare diseases.<\/jats:p>","DOI":"10.1111\/scd.12249","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T11:12:41Z","timestamp":1510744361000},"page":"309-313","source":"Crossref","is-referenced-by-count":11,"title":["Leukocyte adhesion defect\u2010I: rare primary immune deficiency"],"prefix":"10.1111","volume":"37","author":[{"given":"Nitesh","family":"Tewari","sequence":"first","affiliation":[{"name":"Pedodontics and Preventive Dentistry, Centre for Dental Education and Research, All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay Prakash","family":"Mathur","sequence":"additional","affiliation":[{"name":"Pedodontics and Preventive Dentistry, Centre for Dental Education and Research, All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikender Singh","family":"Yadav","sequence":"additional","affiliation":[{"name":"Periodontics, Centre for Dental Education and Research, All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhat","family":"Chaudhari","sequence":"additional","affiliation":[{"name":"Orthodontics and Dentofacial Deformities, Centre for Dental Education and Research, All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,15]]},"container-title":["Special Care in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fscd.12249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/scd.12249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T16:48:59Z","timestamp":1696006139000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/scd.12249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/scd.12249"],"URL":"https:\/\/doi.org\/10.1111\/scd.12249","archive":["Portico"],"relation":{},"ISSN":["0275-1879","1754-4505"],"issn-type":[{"value":"0275-1879","type":"print"},{"value":"1754-4505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]}}}