{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:28:46Z","timestamp":1783394926430,"version":"3.54.6"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The purpose of this study was to \u00adexamine the use of oral clonidine as a preoperative sedative prior to parenteral moderate sedation. Initially, four patients were given 0.2 mg oral clonidine but reduced to 0.1 mg clonidine due to \u00adsignificant drops in blood pressure. Oral clonidine doses of 0.1 mg were then given to 19 patients preoperatively. In all these patients, blood pressure measurements decreased, but there were no significant differences in amounts of sedative agents needed in the clonidine group and the control group (N = 80). The conclusions reached suggest that clonidine has an advantage over other preoperative sedation agents in anxious patients exhibiting hypertension and tachycardia. However, the preop ideal dose required to reduce the amount of sedative drugs used as well as provide anxiolysis remains unknown. In further studies, different doses should be explored to determine what dosage of clonidine may offer hemodynamic protection as well as decrease sedative drugs needed.<\/jats:p>","DOI":"10.1111\/scd.12269","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T13:42:51Z","timestamp":1516801371000},"page":"80-88","source":"Crossref","is-referenced-by-count":3,"title":["Clonidine as a preoperative sedative"],"prefix":"10.1111","volume":"38","author":[{"given":"Robert G.","family":"Henry","sequence":"first","affiliation":[{"name":"Chief of Dental Services, Department of Veterans Affairs Medical Center, Lexington, Kentucky and Associate Professor College of Dentistry of Kentucky  Lexington Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted P.","family":"Raybould","sequence":"additional","affiliation":[{"name":"Program Director, Kentucky Clinic and Professor College of Dentistry University of Kentucky  Lexington Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli","family":"Romond","sequence":"additional","affiliation":[{"name":"Director of Dental Research Staff Dentist VA Dental Service Department of Veterans Affairs Medical Center  Lexington Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios E.","family":"Kouzoukas","sequence":"additional","affiliation":[{"name":"Research Assistant Professor Department of Molecular Pharmacology &amp; Therapeutics Loyola University Chicago Stritch School of Medicine  Maywood Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra D.","family":"Challman","sequence":"additional","affiliation":[{"name":"University of Kentucky, Lexington  Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001711"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7070.1448a"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2344\/0003-3006(2006)53[34:OCPPTV]2.0.CO;2"},{"issue":"3","key":"e_1_2_5_5_1","first-page":"6","article-title":"Try it, You'll Like it","volume":"43","author":"Todd D.","year":"2010","journal-title":"ASDA Newsletter, The Pulse"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1981.tb01217.x"},{"issue":"9","key":"e_1_2_5_7_1","first-page":"453","article-title":"Oral premedication with clonidine as an alternative in dental practice. The effects on the pain threshold, blood pressure and salivary flow","volume":"47","author":"Fanini D","year":"1998","journal-title":"Minerva Stomatol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-5946"},{"issue":"3","key":"e_1_2_5_9_1","first-page":"135","article-title":"Effects of clonidine on intravenous sedation with midazolam","volume":"42","author":"Murai T","year":"1995","journal-title":"Anesth Prog"},{"issue":"3","key":"e_1_2_5_10_1","first-page":"214","article-title":"Clonidine in oral medicine. Literature review and our experience","volume":"115","author":"Mutzbauer TS","year":"2005","journal-title":"Schweiz Monatsschr Zahnmed"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500915"},{"issue":"5","key":"e_1_2_5_12_1","first-page":"870","article-title":"A.P. K. Comparison of oral clonidine and midazolam as premedications in children","volume":"6","author":"Mahajan RK","year":"2012","journal-title":"J Clin Diagnos Res"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-012-0319-8"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199801000-00018"},{"issue":"3","key":"e_1_2_5_15_1","first-page":"259","article-title":"Premedication with clonidine before TIVA optimizes namic surgical field visualization and shortens duration of endoscopic sinus surgery \u2013 results of a clinical trial","volume":"51","author":"Wawrzniak K","year":"2013","journal-title":"Rhinology"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000000660"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2016.01.004"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9185.182112"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2016.08.008"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2017.02.003"}],"container-title":["Special Care in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fscd.12269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/scd.12269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T01:45:43Z","timestamp":1695692743000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/scd.12269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,24]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/scd.12269"],"URL":"https:\/\/doi.org\/10.1111\/scd.12269","archive":["Portico"],"relation":{},"ISSN":["0275-1879","1754-4505"],"issn-type":[{"value":"0275-1879","type":"print"},{"value":"1754-4505","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,24]]}}}