{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:47:17Z","timestamp":1759938437916},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T00:00:00Z","timestamp":1526947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Special Care in Dentistry"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML). All\u2010<jats:italic>trans<\/jats:italic> retinoic acid (ATRA) is the first\u2010choice therapy for the treatment of this disease, but has been associated with side effects, the most serious of which is retinoic acid syndrome (RAS). RAS is characterized by unexplained fever, dyspnea, pulmonary infiltrate, leukocytosis and nephropathy. Genital ulcers have been described in some cases, but only two cases of oral ulcers related to this syndrome have been described in the literature. This paper describes the third case of oral ulceration related to ATRA in a 32\u2010year\u2010old white man with diagnosis of APL. Clinicians should know the side effects of ATRA and identify oral ulcers resulting from this therapy. The prompt identification of these ulcers enables the institution of appropriate treatment and can therefore contribute to continuation of the patient's cancer treatment.<\/jats:p>","DOI":"10.1111\/scd.12293","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T12:08:23Z","timestamp":1526990903000},"page":"234-238","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rare labial ulcer related to the use of all\u2010<i>trans<\/i> retinoic acid in a patient with acute promyelocytic leukemia"],"prefix":"10.1111","volume":"38","author":[{"given":"MP","family":"Buligon","sequence":"first","affiliation":[{"name":"University Hospital Federal University of Santa Maria, Roraima Avenue  1000, Building 20; CEP: 97105\u2013900 Santa Maria RS Brazil"},{"name":"Graduate Program in Dental Science Federal University of Santa Maria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JC","family":"Mielke","sequence":"additional","affiliation":[{"name":"University Hospital Federal University of Santa Maria, Roraima Avenue  1000, Building 20; CEP: 97105\u2013900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Chiesa","sequence":"additional","affiliation":[{"name":"University Hospital Federal University of Santa Maria, Roraima Avenue  1000, Building 20; CEP: 97105\u2013900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KL","family":"Ferrazzo","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Dentistry Federal University of Santa Maria, Roraima Avenue  1000, Building 20; CEP: 97105\u2013900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90994-X"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-347872"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-216457"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155214536244"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.2.567.567"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2014105"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12316"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20036"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2000.00306.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2013.56"},{"key":"e_1_2_6_13_1","first-page":"2505","article-title":"Acute promyelocytic leukemia\u202f: from highly fatal to highly curable ASH 50th anniversary review Acute promyelocytic leukemia\u202f: from highly fatal to highly curable","volume":"111","author":"Wang Z","year":"2008","journal-title":"Hematology"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-007-9097-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-150250"},{"key":"e_1_2_6_16_1","first-page":"1704","article-title":"All\u2010trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia","volume":"76","author":"Castaigne S","year":"1990","journal-title":"I. 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